Evidence map›Paper›PMID 36834582›Full record

ArticleInternational journal of molecular sciences2023

Multiple-P450 Gene Co-Up-Regulation in the Development of Permethrin Resistance in the House Fly,

Ming Li, Xuechun Feng, William R Reid, Fang Tang, Nannan Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Ming LiDepartment of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0002-7578-4968
Xuechun FengDepartment of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0003-4313-700X
William R ReidDepartment of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849, USA.
Fang TangDepartment of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849, USA.
Nannan LiuDepartment of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849, USA.
Auburn University · USNanjing Forestry University · CNShenzhen Bay Laboratory · CNUniversity at Buffalo, State University of New York · USUniversity of California San Diego · US

Funding

AAES Hatch/Multistate ALA015-1-10026, ALA015-1-1+
6 · The paper itself

Abstract

This paper reports a study conducted at the whole transcriptome level to characterize the P450 genes involved in the development of pyrethroid resistance, utilizing expression profile analyses of 86 cytochrome P450 genes in house fly strains with different levels of resistance to pyrethroids/permethrin. Interactions among the up-regulated P450 genes and possible regulatory factors in different autosomes were examined in house fly lines with different combinations of autosomes from a resistant house fly strain, ALHF. Eleven P450 genes that were significantly up-regulated, with levels > 2-fold those in the resistant ALHF house flies, were in CYP families 4 and 6 and located on autosomes 1, 3 and 5. The expression of these P450 genes was regulated by trans- and/or cis-acting factors, especially on autosomes 1 and 2. An in vivo functional study indicated that the up-regulated P450 genes also conferred permethrin resistance in

Indexed as

HousefliesInsecticidesAnimalsCytochrome P-450 Enzyme SystemDrosophila melanogasterInsecticide ResistanceMolecular Docking SimulationPermethrinUp-RegulationCytochrome P-450 Enzyme SystemInsecticidesPermethrinD. melanogaster transformationgene functional characterizationhomology modelinginsecticide resistancein vitro metabolismP450 gene overexpression

Identifiers

PMID36834582
PMCPMC9959456
OpenAlexW4319317548

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.