Evidence map›Paper›PMID 36834513›Full record

ArticleInternational journal of molecular sciences2023

Heterogenous Differences in Cellular Senescent Phenotypes in Pre-Eclampsia and IUGR following Quantitative Assessment of Multiple Biomarkers of Senescence.

Samprikta Manna, Colm J Mc Elwain, Gillian M Maher, Marta Giralt Martín, Andrea Musumeci, Fergus P McCarthy, Cathal McCarthy

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Placental Related Disorders of Pregnancy 2.0.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samprikta MannaDepartment of Obstetrics and Gynaecology, Cork University Maternity Hospital, University College Cork, T12 YE02 Cork, Ireland.ORCID 0000-0001-6280-8070
Colm J Mc ElwainDepartment of Pharmacology and Therapeutics, Western Gateway Building, University College Cork, T12 XF62 Cork, Ireland.ORCID 0000-0002-5303-6205
Gillian M MaherINFANT Research Centre, University College Cork, T12 K8AF Cork, Ireland.ORCID 0000-0002-6722-0484
Marta Giralt MartínDepartment of Pharmacology and Therapeutics, Western Gateway Building, University College Cork, T12 XF62 Cork, Ireland.
Andrea MusumeciDepartment of Pharmacology and Therapeutics, Western Gateway Building, University College Cork, T12 XF62 Cork, Ireland.ORCID 0000-0002-2497-0699
Fergus P McCarthyDepartment of Obstetrics and Gynaecology, Cork University Maternity Hospital, University College Cork, T12 YE02 Cork, Ireland.
Cathal McCarthyDepartment of Pharmacology and Therapeutics, Western Gateway Building, University College Cork, T12 XF62 Cork, Ireland.ORCID 0000-0002-9514-9021

Funding

European Union's Horizon 2020 765274
6 · The paper itself

Abstract

Premature ageing of the placenta in pregnancy outcomes is associated with the persistent presence of oxidative stress and placental insufficiency reducing its functional capacity. In this study, we investigated cellular senescence phenotypes of pre-eclampsia and IUGR pregnancies by simultaneously measuring several biomarkers of senescence. Maternal plasma and placental samples were collected at term gestation from nulliparous women undergoing pre-labour elective caesarean section with pre-eclampsia without intrauterine growth restriction (PE;

Indexed as

Fetal Growth RetardationPre-EclampsiaBiomarkersCellular SenescenceCesarean SectionFemaleHumansPhenotypePlacentaPregnancyProliferating Cell Nuclear AntigenBiomarkersProliferating Cell Nuclear Antigencellular senescenceintrauterine growth restrictionplacental ageingpre-eclampsia

Identifiers

PMID36834513
PMCPMC9963163

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.