Evidence map›Paper›PMID 36834510›Full record

ArticleInternational journal of molecular sciences2023

Sphingoid Bases Regulate the Sigma-1 Receptor-Sphingosine and

Jing Li, Kenneth A Satyshur, Lian-Wang Guo, Arnold E Ruoho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Choline-An Essential Nutrient with Health Benefits and a Signaling Molecule.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jing LiDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Kenneth A SatyshurSmall Molecule Screening Facility, Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.ORCID 0000-0001-9371-2493
Lian-Wang GuoDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-6947-1578
Arnold E RuohoDepartment of Neuroscience, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.
University of Virginia · USUniversity of Wisconsin–Madison · US

Funding

Master epigenetic regulators and retinal degenerative diseaseR01EY029809 · NEI · UNIVERSITY OF VIRGINIA · PI GUO, LIANWANG · 2019 to 2022
$1.6M
NEI NIH HHS R01 EY029809
6 · The paper itself

Abstract

Both bioactive sphingolipids and Sigma-1 receptor (S1R) chaperones occur ubiquitously in mammalian cell membranes. Endogenous compounds that regulate the S1R are important for controlling S1R responses to cellular stress. Herein, we interrogated the S1R in intact Retinal Pigment Epithelial cells (ARPE-19) with the bioactive sphingoid base, sphingosine (SPH), or the pain-provoking dimethylated SPH derivative,

Indexed as

Receptors, sigmaSphingosineAnimalsCeramidesMammalsSigma-1 ReceptorSphingolipidsCeramidesReceptors, sigmaSigma-1 ReceptorSphingolipidsSphingosineceramideendogenous agonistsmodified native gel approachmolecular dockingN,N’-dimethylsphingosinesigma-1 receptorsphingosine

Identifiers

PMID36834510
PMCPMC9962145
OpenAlexW4319318682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.