Evidence map›Paper›PMID 36834493›Full record

ArticleInternational journal of molecular sciences2023

Sarah Abdul Majeed, Helene Dunzendorfer, Juliane Weiner, John T Heiker, Wieland Kiess, Antje Körner, Kathrin Landgraf

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sarah Abdul MajeedCenter for Pediatric Research Leipzig (CPL), Hospital for Children & Adolescents, University of Leipzig, 04103 Leipzig, Germany.
Helene DunzendorferCenter for Pediatric Research Leipzig (CPL), Hospital for Children & Adolescents, University of Leipzig, 04103 Leipzig, Germany.
Juliane WeinerMedical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.
John T HeikerMedical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.ORCID 0000-0003-2822-3006
Wieland KiessCenter for Pediatric Research Leipzig (CPL), Hospital for Children & Adolescents, University of Leipzig, 04103 Leipzig, Germany.
Antje KörnerCenter for Pediatric Research Leipzig (CPL), Hospital for Children & Adolescents, University of Leipzig, 04103 Leipzig, Germany.
Kathrin LandgrafCenter for Pediatric Research Leipzig (CPL), Hospital for Children & Adolescents, University of Leipzig, 04103 Leipzig, Germany.ORCID 0000-0002-6878-6033
Helmholtz Zentrum München · DE

Funding

Deutsche Diabetes Gesellschaft Hagedorn ProjektförderungDeutsche Forschungsgemeinschaft Projektnummer 209933838 - SFB 1052 project C05 to A.K. and C07 to J.T.H.Federal Ministry of Education and Research FKZ: 01EO1501 (IFB Adiposity Diseases)
6 · The paper itself

Abstract

Obesity is already accompanied by adipose tissue (AT) dysfunction and metabolic disease in children and increases the risk of premature death. Due to its energy-dissipating function, brown AT (BAT) has been discussed as being protective against obesity and related metabolic dysfunction. To analyze the molecular processes associated with BAT development, we investigated genome-wide expression profiles in brown and white subcutaneous and perirenal AT samples of children. We identified 39 upregulated and 26 downregulated genes in uncoupling protein 1 (UCP1)-positive compared to UCP1-negative AT samples. We prioritized for genes that had not been characterized regarding a role in BAT biology before and selected cordon-bleu WH2 repeat protein (

Indexed as

Adipose Tissue, BrownObesityAdipocytes, BrownAdipose Tissue, WhiteChildCytoskeletal ProteinsEye ProteinsHomeodomain ProteinsHumansMicrofilament ProteinsMyocilinThermogenesisUncoupling Protein 1Cobl protein, humanCytoskeletal ProteinsEye ProteinsHomeodomain ProteinsMicrofilament ProteinsMKX protein, humanMyocilinUncoupling Protein 1adipocyte differentiationadipose tissuebrown adipose tissuechildrenCOBLmetabolic diseaseMKXMYOCobesitywhite adipose tissue

Identifiers

PMID36834493
PMCPMC9964948
OpenAlexW4319318705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.