Evidence map›Paper›PMID 36834472›Full record

ArticleInternational journal of molecular sciences2023

A Picrocrocin-Enriched Fraction from a Saffron Extract Affects Lipid Homeostasis in HepG2 Cells through a Non-Statin-like Mode.

Luca Frattaruolo, Federica Marra, Graziantonio Lauria, Carlo Siciliano, Rosita Curcio, Luigina Muto, Matteo Brindisi, Donatella Aiello, Anna Napoli, Giuseppe Fiermonte and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Nutrients · 2023
    Article
  7. Cell Metabolism Therapy by Small Natural Compounds.International journal of molecular sciences · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Luca FrattaruoloDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.ORCID 0000-0002-7018-8454
Federica MarraDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.
Graziantonio LauriaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.ORCID 0000-0002-6676-0585
Carlo SicilianoDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.ORCID 0000-0002-0584-219X
Rosita CurcioDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.ORCID 0000-0002-4077-0101
Luigina MutoDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.
Matteo BrindisiDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.ORCID 0000-0002-5022-9642
Donatella AielloDepartment of Chemistry and Chemical Technologies, University of Calabria, 87036 Arcavacata di Rende, Italy.ORCID 0000-0003-1866-2486
Anna NapoliDepartment of Chemistry and Chemical Technologies, University of Calabria, 87036 Arcavacata di Rende, Italy.ORCID 0000-0002-7004-7643
Giuseppe FiermonteDepartment of Biosciences, Biotechnologies and Environment, University of Bari, 70125 Bari, Italy.ORCID 0000-0002-6764-9395
Anna Rita CappelloDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.
Marco FiorilloDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.ORCID 0000-0002-8055-3259
Amer AhmedDepartment of Biosciences, Biotechnologies and Environment, University of Bari, 70125 Bari, Italy.ORCID 0000-0002-0503-4045
Vincenza DolceDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.ORCID 0000-0003-2966-4866
University of Calabria · ITUniversity of Bari Aldo Moro · IT

Funding

Ministry of Education, Universities and Research 2017PAB8EM_002Ministry of Education, Universities and Research 2017PAB8EM_003
6 · The paper itself

Abstract

Dyslipidemia is a lipid metabolism disorder associated with the loss of the physiological homeostasis that ensures safe levels of lipids in the organism. This metabolic disorder can trigger pathological conditions such as atherosclerosis and cardiovascular diseases. In this regard, statins currently represent the main pharmacological therapy, but their contraindications and side effects limit their use. This is stimulating the search for new therapeutic strategies. In this work, we investigated in HepG2 cells the hypolipidemic potential of a picrocrocin-enriched fraction, analyzed by high-resolution

Indexed as

CrocusCyclohexenesGlucosidesHep G2 CellsHumansPlant ExtractsTerpenesCyclohexenesGlucosidespicrocrocinPlant ExtractsTerpenesHepG2 cellshypolipidemic activitylipid metabolismlow-density lipoprotein receptor (LDLR)picrocrocinsaffron extract

Identifiers

PMID36834472
PMCPMC9965904
OpenAlexW4319319072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.