The Impact of Harsh Stratospheric Conditions on Survival and Antibiotic Resistance Profile of Non-Spore Forming Multidrug Resistant Human Pathogenic Bacteria Causing Hospital-Associated Infections.

Ignacy Górecki, Agata Kołodziejczyk, Matt Harasymczuk, Grażyna Młynarczyk, Ksenia Szymanek-Majchrzak

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In one paragraph

Article in International journal of environmental research and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.3field-weighted citation impact, top 56% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ignacy GóreckiDepartment of Medical Microbiology, Medical University of Warsaw, Chalubinskiego, Str. 5, 02-004 Warsaw, Poland.

Agata KołodziejczykAnalog Astronaut Training Center, Morelowa Str. 1F/4, 30-222 Cracow, Poland.

Matt HarasymczukAnalog Astronaut Training Center, Morelowa Str. 1F/4, 30-222 Cracow, Poland.ORCID 0000-0002-2961-0617

Grażyna MłynarczykDepartment of Medical Microbiology, Medical University of Warsaw, Chalubinskiego, Str. 5, 02-004 Warsaw, Poland.

Ksenia Szymanek-MajchrzakDepartment of Medical Microbiology, Medical University of Warsaw, Chalubinskiego, Str. 5, 02-004 Warsaw, Poland.ORCID 0000-0003-4314-3522

Medical University of Warsaw · PLAGH University of Krakow · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteria are constantly being lifted to the stratosphere due to air movements caused by weather phenomena, volcanic eruptions, or human activity. In the upper parts of the atmosphere, they are exposed to extremely harsh and mutagenic conditions such as UV and space radiation or ozone. Most bacteria cannot withstand that stress, but for a fraction of them, it can act as a trigger for selective pressure and rapid evolution. We assessed the impact of stratospheric conditions on the survival and antibiotic resistance profile of common non-spore-forming human pathogenic bacteria, both sensitive and extremely dangerous multidrug-resistant variants, with plasmid-mediated mechanisms of resistance. Pseudomonas aeruginosa did not survive the exposure. In the case of strains that were recovered alive, the survival was extremely low: From 0.00001% of

Indexed as

Cross InfectionMethicillin-Resistant Staphylococcus aureusAnti-Bacterial AgentsBacteriaDrug Resistance, Multiple, BacterialHospitalsHumansMicrobial Sensitivity TestsStaphylococcus aureusVancomycinAnti-Bacterial AgentsVancomycinantibiotic resistanceastrobiologyhospital-associated infections (HAI)human pathogenic bacteriastratospheric flight

Identifiers

PMID36833485

DOI10.3390/ijerph20042787

PMCPMC9956888

OpenAlexW4319318580

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.