Evidence map›Paper›PMID 36833445›Full record

ArticleGenes2023

Genetic Interaction of tRNA-Dependent Mistranslation with Fused in Sarcoma Protein Aggregates.

Jeremy T Lant, Farah Hasan, Julia Briggs, Ilka U Heinemann, Patrick O'Donoghue

Open access · goldAbstract read
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Natural human tRNARNA (New York, N.Y.) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jeremy T LantDepartment of Biochemistry, The University of Western Ontario, London, ON N6A 5C1, Canada.ORCID 0000-0002-9030-0845
Farah HasanDepartment of Biochemistry, The University of Western Ontario, London, ON N6A 5C1, Canada.
Julia BriggsDepartment of Biochemistry, The University of Western Ontario, London, ON N6A 5C1, Canada.
Ilka U HeinemannDepartment of Biochemistry, The University of Western Ontario, London, ON N6A 5C1, Canada.
Patrick O'DonoghueDepartment of Biochemistry, The University of Western Ontario, London, ON N6A 5C1, Canada.ORCID 0000-0002-9500-8640
Western University · CA

Funding

CIHR 165985
6 · The paper itself

Abstract

High-fidelity protein synthesis requires properly aminoacylated transfer RNAs (tRNAs), yet diverse cell types, from bacteria to humans, show a surprising ability to tolerate errors in translation resulting from mutations in tRNAs, aminoacyl-tRNA synthetases, and other components of protein synthesis. Recently, we characterized a tRNA

Indexed as

Amyotrophic Lateral SclerosisNeurodegenerative DiseasesSarcomaHumansProtein AggregatesRNA, TransferRNA, Transfer, SerProtein AggregatesRNA, TransferRNA, Transfer, Seramyotrophic lateral sclerosis (ALS)fused in sarcoma (FUS) proteinmistranslationprotein aggregationprotein synthesistransfer RNA (tRNA)

Identifiers

PMID36833445
PMCPMC9956149
OpenAlexW4321373232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.