Evidence map›Paper›PMID 36833412›Full record

ArticleGenes2023

A Chemoptogenetic Tool for Spatiotemporal Induction of Oxidative DNA Lesions

Suhao Han, Austin Sims, Anthony Aceto, Brigitte F Schmidt, Marcel P Bruchez, Aditi U Gurkar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Suhao HanAging Institute of UPMC, The University of Pittsburgh School of Medicine, 100 Technology Dr, Pittsburgh, PA 15219, USA.ORCID 0000-0001-6013-9467
Austin SimsAging Institute of UPMC, The University of Pittsburgh School of Medicine, 100 Technology Dr, Pittsburgh, PA 15219, USA.
Anthony AcetoAging Institute of UPMC, The University of Pittsburgh School of Medicine, 100 Technology Dr, Pittsburgh, PA 15219, USA.
Brigitte F SchmidtMolecular Biosensor and Imaging Center, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.ORCID 0000-0002-2892-493X
Marcel P BruchezMolecular Biosensor and Imaging Center, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.ORCID 0000-0002-7370-4848
Aditi U GurkarAging Institute of UPMC, The University of Pittsburgh School of Medicine, 100 Technology Dr, Pittsburgh, PA 15219, USA.ORCID 0000-0003-4338-0624
University of Pittsburgh · USImaging Center · US

Funding

TriState SenNET (Lung and Heart) Tissue Map and Atlas consortiumU54AG075931 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TOREN FINKEL, Melanie Koenigshoff · 2021 to 2026
$14.0M
Mapping the cell specific DNA damage-induced molecular and bioelectrical responses in the 3D cardiac unitR01HL161106 · NHLBI · CARNEGIE-MELLON UNIVERSITY · PI Tzahi Cohen-Karni, Aditi U Gurkar · 2022 to 2026
$3.1M
Modulators of DNA damage associated nucleo-mitochondrial communication in agingR00AG049126 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GURKAR, ADITI U · 2017 to 2019
$835k
NHLBI NIH HHS R01 HL161106NIA NIH HHS R00 AG049126NIA NIH HHS U54 AG075931
6 · The paper itself

Abstract

Oxidative nuclear DNA damage increases in all tissues with age in multiple animal models, as well as in humans. However, the increase in DNA oxidation varies from tissue to tissue, suggesting that certain cells/tissues may be more vulnerable to DNA damage than others. The lack of a tool that can control dosage and spatiotemporal induction of oxidative DNA damage, which accumulates with age, has severely limited our ability to understand how DNA damage drives aging and age-related diseases. To overcome this, here we developed a chemoptogenetic tool that produces 8-oxoguanine (8-oxoG) at DNA in a whole organism,

Indexed as

Oxidative StressSinglet OxygenAgingAnimalsCaenorhabditis elegansDNADNA DamageHumansDNASinglet OxygenagingDNA damageoptogeneticROS

Identifiers

PMID36833412
PMCPMC9956269
OpenAlexW4320919276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.