Evidence map›Paper›PMID 36833408›Full record

ArticleGenes2023

TCF7L1 Regulates

Carli M King, Olivia M Marx, Wei Ding, Walter A Koltun, Gregory S Yochum

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Carli M KingDepartment of Biochemistry & Molecular Biology, College of Medicine, The Pennsylvania State University, Hershey, PA 17036, USA.
Olivia M MarxDepartment of Biochemistry & Molecular Biology, College of Medicine, The Pennsylvania State University, Hershey, PA 17036, USA.
Wei DingDepartment of Surgery, Division of Colon & Rectal Surgery, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17036, USA.
Walter A KoltunDepartment of Surgery, Division of Colon & Rectal Surgery, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17036, USA.
Gregory S YochumDepartment of Biochemistry & Molecular Biology, College of Medicine, The Pennsylvania State University, Hershey, PA 17036, USA.
Pennsylvania State University · USPenn State Milton S. Hershey Medical Center · US

Funding

Dissecting the role of TCF7L1 in colorectal cancerR03CA244133 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI YOCHUM, GREGORY S. · 2020 to 2020
$158k
NCI NIH HHS CA244133NCI NIH HHS R03 CA244133
6 · The paper itself

Abstract

Mutations in components of the Wnt/β-catenin signaling pathway drive colorectal cancer (CRC), in part, by deregulating expression of genes controlled by the T-cell factor (TCF) family of transcription factors. TCFs contain a conserved DNA binding domain that mediates association with TCF binding elements (TBEs) within Wnt-responsive DNA elements (WREs). Intestinal stem cell marker, leucine-rich-repeat containing G-protein-coupled receptor 5 (LGR5), is a Wnt target gene that has been implicated in CRC stem cell plasticity. However, the WREs at the

Indexed as

Colorectal NeoplasmsReceptors, G-Protein-CoupledTranscription Factor 7-Like 1 Proteinbeta CateninHumansNeoplastic Stem CellsTranscription Factorsbeta CateninLGR5 protein, humanReceptors, G-Protein-CoupledTCF7L1 protein, humanTranscription Factor 7-Like 1 ProteinTranscription Factorscolorectal cancerLGR5spheroidsT-cell factorsTCF7L1WNTWnt-responsive DNA elements

Identifiers

PMID36833408
PMCPMC9956233
OpenAlexW4320728830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.