Evidence map›Paper›PMID 36833380›Full record

ArticleGenes2023

Impact of pri-let-7a-1 rs10739971 for Gastric Cancer Predisposition in an Amazon Region.

Roberta Borges Andrade, Amanda de Nazaré Cohen-Paes, Diana Feio da Veiga Borges Leal, Karla Beatriz Cardias Cereja Pantoja, Laura Patrícia Albarello Gellen, Darlen Cardoso de Carvalho, Tatiane Piedade de Souza, Marianne Rodrigues Fernandes, Paulo Pimentel de Assumpcão, Rommel Mario Rodríguez Burbano and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Molecular Profile of Variants inJournal of personalized medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Roberta Borges AndradeOncology Research Center, Federal University of Pará, Belém 66073-000, Pará, Brazil.
Amanda de Nazaré Cohen-PaesOncology Research Center, Federal University of Pará, Belém 66073-000, Pará, Brazil.ORCID 0000-0003-3548-292X
Diana Feio da Veiga Borges LealOncology Research Center, Federal University of Pará, Belém 66073-000, Pará, Brazil.ORCID 0000-0003-3125-6052
Karla Beatriz Cardias Cereja PantojaOncology Research Center, Federal University of Pará, Belém 66073-000, Pará, Brazil.ORCID 0000-0002-1278-3722
Laura Patrícia Albarello GellenOncology Research Center, Federal University of Pará, Belém 66073-000, Pará, Brazil.ORCID 0000-0001-8620-5987
Darlen Cardoso de CarvalhoOncology Research Center, Federal University of Pará, Belém 66073-000, Pará, Brazil.ORCID 0000-0002-2716-860X
Tatiane Piedade de SouzaOncology Research Center, Federal University of Pará, Belém 66073-000, Pará, Brazil.
Marianne Rodrigues FernandesOncology Research Center, Federal University of Pará, Belém 66073-000, Pará, Brazil.ORCID 0000-0002-1396-3442
Paulo Pimentel de AssumpcãoOncology Research Center, Federal University of Pará, Belém 66073-000, Pará, Brazil.
Rommel Mario Rodríguez BurbanoOncology Research Center, Federal University of Pará, Belém 66073-000, Pará, Brazil.ORCID 0000-0002-4872-234X
Sidney Emanuel Batista Dos SantosOncology Research Center, Federal University of Pará, Belém 66073-000, Pará, Brazil.
Ney Pereira Carneiro Dos SantosOncology Research Center, Federal University of Pará, Belém 66073-000, Pará, Brazil.
Universidade Federal do Pará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) is the fifth most common type of cancer and the fourth leading cause of cancer death. In Brazil, GC has a high incidence and mortality rates, and it is highly variable by region. The Amazon region has significant rising rates among all Brazil regions. Only very few studies have evaluated the association between genetic variants and the risk of gastric cancer in the Brazilian Amazon population. Therefore, this study aimed to investigate associations between single nucleotide polymorphisms of miRNA processing genes and the risk for GC in this population. Potentially functional single nucleotide polymorphisms from miRNA processing genes were genotyped in 159 cases and 193 healthy controls by QuantStudio Real Time PCR. According to our findings, the genotype GG of the variant rs10739971 presents a lower risk to the development of GC in comparison to the remaining genotypes (

Indexed as

MicroRNAsStomach NeoplasmsGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotideMicroRNAsmirnlet7 microRNA, humanAmazoncancer predispositiongastric cancer

Identifiers

PMID36833380
PMCPMC9956087
OpenAlexW4319985758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.