Evidence map›Paper›PMID 36833277›Full record

ArticleGenes2023

COMT but Not 5HTTLPR Gene Is Associated with Depression in First-Episode Psychosis: The Role of Stressful Life Events.

Sarah Tosato, Chiara Bonetto, Katia De Santi, Antonio Lasalvia, Massimo Gennarelli, Doriana Cristofalo, Mariaelena Bertani, Mirella Ruggeri, On Behalf Of The Picos-Veneto Group

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sarah TosatoDepartment of Neuroscience, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-9665-7538
Chiara BonettoDepartment of Neuroscience, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, 37134 Verona, Italy.
Katia De SantiAzienda Ospedaliera Universitaria Integrata, Unit of Psychiatry B, 37134 Verona, Italy.
Antonio LasalviaDepartment of Neuroscience, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-9963-6081
Massimo GennarelliDepartment of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy.
Doriana CristofaloDepartment of Neuroscience, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, 37134 Verona, Italy.
Mariaelena BertaniAzienda Ospedaliera Universitaria Integrata, Unit of Psychiatry B, 37134 Verona, Italy.
Mirella RuggeriDepartment of Neuroscience, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, 37134 Verona, Italy.
On Behalf Of The Picos-Veneto Group
University of Verona · ITAzienda Ospedaliera Universitaria Integrata Verona · ITCentro San Giovanni di Dio Fatebenefratelli · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serotonergic and dopaminergic systems are involved in the regulation of mood and reactivity to psychological stress. This study explores, in a sample of first episode psychosis (FEP) patients, whether more severe depressive symptoms were found in those who: (1) experienced a major stressful event in the 6 months preceding illness onset; and (2) were homozygous for the COMT Val158 allele or carrying the S allele of 5-HTTLPR. A total of 186 FEP patients recruited were assessed using the Hamilton Rating Scale for Depression (HAMD) for depressive symptoms. Stressful life events (SLEs) were collected by the List of Events Scale. The genotypes of 5-HTTLPR, rs25531, and COMT Val158 Met were performed. It has been found that higher levels of depression is associated with the presence of SLEs (

Indexed as

DepressionPsychotic DisordersCatechol O-MethyltransferaseGenotypeHumansLife Change EventsStress, PsychologicalCatechol O-MethyltransferaseCOMT protein, human5-HTTLPRCOMTdepressionfirst-episode psychosisstressful life events

Identifiers

PMID36833277
PMCPMC9956580
OpenAlexW4318477426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.