Evidence map›Paper›PMID 36833213›Full record

ArticleGenes2023

Ablation of

Linn Amanda Syding, Agnieszka Kubik-Zahorodna, David Pajuelo Reguera, Petr Nickl, Bohdana Hruskova, Michaela Kralikova, Jana Kopkanova, Vendula Novosadova, Petr Kasparek, Jan Prochazka and 3 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Chromosome-length genome assembly ofbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Linn Amanda SydingLaboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the CAS, 25250 Vestec, Czech Republic.
Agnieszka Kubik-ZahorodnaCzech Centre for Phenogenomics, Institute of Molecular Genetics of the CAS, 25250 Vestec, Czech Republic.
David Pajuelo RegueraCzech Centre for Phenogenomics, Institute of Molecular Genetics of the CAS, 25250 Vestec, Czech Republic.ORCID 0000-0002-7715-9402
Petr NicklLaboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the CAS, 25250 Vestec, Czech Republic.ORCID 0000-0002-4289-0502
Bohdana HruskovaDepartment of Auditory Neuroscience, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Michaela KralikovaDepartment of Auditory Neuroscience, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Jana KopkanovaCzech Centre for Phenogenomics, Institute of Molecular Genetics of the CAS, 25250 Vestec, Czech Republic.
Vendula NovosadovaCzech Centre for Phenogenomics, Institute of Molecular Genetics of the CAS, 25250 Vestec, Czech Republic.
Petr KasparekCzech Centre for Phenogenomics, Institute of Molecular Genetics of the CAS, 25250 Vestec, Czech Republic.
Jan ProchazkaLaboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the CAS, 25250 Vestec, Czech Republic.
Jan RozmanCzech Centre for Phenogenomics, Institute of Molecular Genetics of the CAS, 25250 Vestec, Czech Republic.ORCID 0000-0002-8035-8904
Rostislav TurecekDepartment of Auditory Neuroscience, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Radislav SedlacekLaboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the CAS, 25250 Vestec, Czech Republic.ORCID 0000-0002-3352-392X
Czech Academy of Sciences, Institute of Molecular Genetics · CZCzech Academy of Sciences, Institute of Experimental Medicine · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress responses are activated by the hypothalamic-pituitary-adrenal axis (HPA axis), culminating in the release of glucocorticoids. During prolonged periods of secretion of glucocorticoids or inappropriate behavioral responses to a stressor, pathologic conditions may occur. Increased glucocorticoid concentration is linked to generalized anxiety, and there are knowledge gaps regarding its regulation. It is known that the HPA axis is under GABAergic control, but the contribution of the individual subunits of the GABA receptor is largely unknown. In this study, we investigated the relationship between the α5 subunit and corticosterone levels in a new mouse model deficient for

Indexed as

CorticosteroneGlucocorticoidsAnimalsAnxietyHumansHypothalamo-Hypophyseal SystemMicePituitary-Adrenal SystemReceptors, GABAReceptors, GABA-ACorticosteroneGABRA5 protein, humanGabra5 protein, mouseGlucocorticoidsReceptors, GABAReceptors, GABA-AanxietybehaviorcorticosteroneGABA receptormouse model

Identifiers

PMID36833213
PMCPMC9956889
OpenAlexW4317930414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.