Evidence map›Paper›PMID 36833148›Full record

ReviewHealthcare (Basel, Switzerland)2023

Multidisciplinary Approach to the Diagnosis and Therapy of Mycosis Fungoides.

Paola Vitiello, Caterina Sagnelli, Andrea Ronchi, Renato Franco, Stefano Caccavale, Maria Mottola, Francesco Pastore, Giuseppe Argenziano, Massimiliano Creta, Armando Calogero and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Healthcare (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Paola VitielloDermatology Unit, University of Campania Luigi Vanvitelli, 80131 Naples, Italy.
Caterina SagnelliDepartment of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, 80131 Naples, Italy.ORCID 0000-0002-6413-7810
Andrea RonchiPathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, 80131 Naples, Italy.
Renato FrancoPathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, 80131 Naples, Italy.
Stefano CaccavaleDermatology Unit, University of Campania Luigi Vanvitelli, 80131 Naples, Italy.
Maria MottolaDepartment of Heart Surgery and Transplantations, AORN Dei Colli-V Monaldi, 80131 Naples, Italy.
Francesco PastoreRadiotherapy Unit, Emicenter, 80020 Naples, Italy.
Giuseppe ArgenzianoDermatology Unit, University of Campania Luigi Vanvitelli, 80131 Naples, Italy.
Massimiliano CretaDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0003-2082-3330
Armando CalogeroDepartment of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Alfonso FiorelliThoracic Surgery Unit, University of Campania Luigi Vanvitelli, 80131 Naples, Italy.ORCID 0000-0002-0628-613X
Beniamino CasaleDepartment of Pneumology and Tisiology, AO Dei Colli-V. Monaldi, 80131 Naples, Italy.
Antonello SicaDepartment of Precision Medicine, University of Campania Luigi Vanvitelli, 80131 Naples, Italy.ORCID 0000-0002-8676-4620
University of Campania "Luigi Vanvitelli" · ITOspedale Monaldi · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycosis fungoides is the most common primary cutaneous T-cell lymphoma, characterized by skin-homing CD4+ T cells derivation, indolent course, and low-grade of malignancy. Mycosis fungoides's classic type typically onsets with cutaneous erythematous patches, plaque, and tumor. In WHO-EORTC classification, folliculotropic mycosis fungoides, pagetoid reticulosis, and granulomatous slack skin are recognized as distinct variants of mycosis fungoides, because of their clinical and histological features, behavior, and /or prognosis. Mycosis fungoides often shows diagnostic difficulties, due to its absence of specific features and lesional polymorphism. A patient's treatment requires staging. In about 10% of cases, mycosis fungoides can progress to lymph nodes and internal organs. Prognosis is poor at advanced stage and management needs a multidisciplinary team approach. Advanced stage disease including tumors, erythroderma, and nodal, visceral, or blood involvement needs skin directed therapy associated with systemic drugs. Skin directed therapy includes steroids, nitrogen mustard, bexarotene gel, phototherapy UVB, and photochemiotherapy, i.e., total skin electron radiotherapy. Systemic therapies include retinoids, bexarotene, interferon, histone deacetylase inhibitors, photopheresis, targeted immunotherapy, and cytotoxic chemotherapy. Complexity of mycosis fungoides associated with long-term chronic evolution and multiple therapy based on disease stage need a multidisciplinary team approach to be treated.

Indexed as

CTCL1early mycosis fungoidesmultidisciplinary team approachmycosis fungoidesprimary cutaneous T-cell lymphoma

Identifiers

PMID36833148
PMCPMC9957453
OpenAlexW4321372295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.