Evidence map›Paper›PMID 36833093›Full record

ReviewHealthcare (Basel, Switzerland)2023

Emerging Therapeutic Strategies for Diffuse Intrinsic Pontine Glioma: A Systematic Review.

Shahrukh Farrukh, Shagufta Habib, Amna Rafaqat, Zouina Sarfraz, Azza Sarfraz, Muzna Sarfraz, Karla Robles-Velasco, Miguel Felix, Ivan Cherrez-Ojeda

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Healthcare (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Frequency and outcomes of midline gliomas in a tertiary care hospital in Pakistan: a retrospective study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Shahrukh FarrukhDepartment of Research, Khawaja Muhammad Safdar Medical College, Sialkot 51310, Pakistan.
Shagufta HabibDepartment of Research, University Medical and Dental College Faisalabad, Faisalabad 38800, Pakistan.
Amna RafaqatDepartment of Research and Publications, Fatima Jinnah Medical University, Lahore 54000, Pakistan.
Zouina SarfrazDepartment of Research and Publications, Fatima Jinnah Medical University, Lahore 54000, Pakistan.ORCID 0000-0002-5132-7455
Azza SarfrazDepartment of Pediatrics and Child Health, The Aga Khan University, Karachi 74000, Pakistan.
Muzna SarfrazIndependent Researcher, Lahore 54000, Pakistan.
Karla Robles-VelascoDepartment of Allergy, Immunology and Pulmonary Medicine, Universidad Espíritu Santo, Samborondón 092301, Ecuador.ORCID 0000-0001-7780-1015
Miguel FelixDepartment of Internal Medicine, New York City Health + Hospitals, Lincoln, The Bronx, NY 10451, USA.ORCID 0000-0002-2243-3646
Ivan Cherrez-OjedaDepartment of Allergy, Immunology and Pulmonary Medicine, Universidad Espíritu Santo, Samborondón 092301, Ecuador.ORCID 0000-0002-1610-239X
Fatima Jinnah Medical University · PKUniversidad de Especialidades Espíritu Santo · ECAga Khan University · PKNew York City Health and Hospitals Corporation · USPunjab Medical College · PKUrban Unit · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOf all central nervous systems tumors, 10-20% are located in the brainstem; diffuse intrinsic pontine glioma (DIPG) is diagnosed in 80% of them. With over five decades of clinical trial testing, there are no established therapeutic options for DIPG. This research article aims to collate recent clinical trial data and provide a landscape for the most promising therapies that have emerged in the past five years.

methodsPubMed/MEDLINE, Web of Science, Scopus, and Cochrane were systematically searched using the following keywords: Diffuse intrinsic pontine glioma, Pontine, Glioma, Treatment, Therapy, Therapeutics, curative, and/or Management. Both adult and pediatric patients with newly diagnosed or progressive DIPG were considered in the clinical trial setting. The risk of bias was assessed using the ROBINS-I tool.

resultsA total of 22 trials were included reporting the efficacy and safety outcomes among patients. First, five trials reported outcomes of blood-brain barrier bypass via single or repeated-dose intra-arterial therapy or convection-enhanced delivery. Second, external beam radiation regimens were assessed for safety and efficacy in three trials. Third, four trials administered intravenous treatment without using chemotherapeutic regimens. Fourth, eight trials reported the combinations of one or more chemotherapeutic agents. Fifth, immunotherapy was reported in two trials in an adjuvant monotherapy in the post-radiotherapy setting.

conclusionThis research article captures a clinical picture of the last five years of the direction toward which DIPG research is heading. The article finds that re-irradiation may prolong survival in patients with progressive DIPG; it also instills that insofar palliative radiotherapy has been a key prognostic choice.

Indexed as

advancesCNSdiffuse intrinsic pontine gliomapalliativequality of lifetherapiestumor

Identifiers

PMID36833093
PMCPMC9956230
OpenAlexW4320728236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.