Evidence map›Paper›PMID 36833088›Full record

ArticleHealthcare (Basel, Switzerland)2023

Benzodiazepine-Receptor Agonist Utilization in Outpatients with Anxiety Disorder: A Retrospective Study Based on Electronic Healthcare Data from a Large General Tertiary Hospital.

Denong Liu, Qingyu Zhang, Zhijia Zhao, Mengjia Chen, Yanbin Hou, Guanjun Wang, Haowei Shen, Huaqiang Zhu, Yunxin Ji, Liemin Ruan and 1 more

Abstract read
In one paragraph

Article in Healthcare (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Denong LiuSchool of Medicine, Ningbo University, Ningbo 315211, China.
Qingyu ZhangDepartment of Psychosomatic Medicine, Zhejiang Regional Medical Center Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo 315010, China.
Zhijia ZhaoSchool of Medicine, Ningbo University, Ningbo 315211, China.
Mengjia ChenDepartment of Pharmacy, Ningbo Yinzhou No.2 Hospital, Ningbo 315199, China.
Yanbin HouDepartment of Psychosomatic Medicine, Zhejiang Regional Medical Center Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo 315010, China.
Guanjun WangDepartment of Psychosomatic Medicine, Zhejiang Regional Medical Center Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo 315010, China.
Haowei ShenSchool of Medicine, Ningbo University, Ningbo 315211, China.
Huaqiang ZhuDepartment of Pharmaceutical Engineering, Zhejiang Pharmaceutical University, Ningbo 315199, China.ORCID 0000-0001-5275-2106
Yunxin JiDepartment of Psychosomatic Medicine, Zhejiang Regional Medical Center Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo 315010, China.
Liemin RuanDepartment of Psychosomatic Medicine, Zhejiang Regional Medical Center Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo 315010, China.
Zhongze LouDepartment of Psychosomatic Medicine, Zhejiang Regional Medical Center Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo 315010, China.ORCID 0000-0002-1757-9368

Funding

Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang 2022E10026Medical and Health Science and Technology Plan Project of Zhejiang Province 2023RC258, 2023KY1062, 2021KY978, 2019KY163Ningbo Health Branding Subject Fund PPXK2018-04Ningbo Key Research and Development Program 2022Z145Ningbo Soft Science Foundation 2022R033Science and Technology Plan Project of Zhejiang Market Supervision Administration ZC2021A043Zhejiang Public Welfare Fund LGF22G030010
6 · The paper itself

Abstract

Benzodiazepine-receptor agonists (BZRAs), including benzodiazepines (BZDs) and drugs related to BZDs (Z-drugs), are commonly used for anxiety, but often have side effects. We retrospectively investigated the utilization and prescription characteristics of BZRAs for patients with anxiety disorders in a large tertiary care general hospital between 2018 and 2021, based on electronic healthcare records. We also examined the pattern of simultaneous consumption of multiple BZRA drugs, and the diseases coexisting with anxiety that are associated with this. The numbers of patients and BZRA prescriptions increased over the 4 years. Moreover, 7195 prescriptions from 694 patients contained two or more BZRAs, of which 78.08% contained both BZDs and Z-drugs, 19.78% contained multiple BZDs, and 2.14% contained multiple Z-drugs. For anxiety patients with concomitant Alzheimer's disease or Parkinson's disease, and dyslipidemia, they were more likely to consume multiple BZRAs simultaneously, whereas patients with concomitant insomnia, depression, hypertension, diabetes, or tumors were less likely to consume multiple BZRAs (all

Indexed as

anxietybenzodiazepinesdrug utilizationmultiple drugsprescriptions

Identifiers

PMID36833088
PMCPMC9956167

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.