Evidence map›Paper›PMID 36832898›Full record

ArticleFoods (Basel, Switzerland)2023

Analytical Platform for the Study of Metabolic Pathway of Propyl Propane Thiosulfonate (PTSO) from

María García-Nicolás, Marta Pastor-Belda, Natalia Campillo, María Jesús Rodríguez-Sojo, Antonio Jesús Ruiz-Malagón, Laura Hidalgo-García, Paloma Abad, José Manuel de la Torre, Enrique Guillamón, Alberto Baños and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Effects of a Diet ofFoods (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

María García-NicolásDepartment of Analytical Chemistry, Faculty of Chemistry, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, E-30100 Murcia, Spain.ORCID 0000-0002-8423-3818
Marta Pastor-BeldaDepartment of Analytical Chemistry, Faculty of Chemistry, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, E-30100 Murcia, Spain.ORCID 0000-0001-7389-0380
Natalia CampilloDepartment of Analytical Chemistry, Faculty of Chemistry, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, E-30100 Murcia, Spain.ORCID 0000-0001-6616-951X
María Jesús Rodríguez-SojoDepartment of Pharmacology, Instituto de Investigación Biosanitaria (ibs. GRANADA), Center for Biomedical Research (CIBM), University of Granada, E-18071 Granada, Spain.
Antonio Jesús Ruiz-MalagónDepartment of Pharmacology, Instituto de Investigación Biosanitaria (ibs. GRANADA), Center for Biomedical Research (CIBM), University of Granada, E-18071 Granada, Spain.
Laura Hidalgo-GarcíaDepartment of Pharmacology, Instituto de Investigación Biosanitaria (ibs. GRANADA), Center for Biomedical Research (CIBM), University of Granada, E-18071 Granada, Spain.
Paloma AbadDepartment of Analytical Chemistry, Faculty of Chemistry, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, E-30100 Murcia, Spain.
José Manuel de la TorreDepartment of Inorganic and Organic Chemistry, Campus of Lagunillas, Universidad de Jaén, E-23071 Jaén, Spain.ORCID 0000-0002-1419-5123
Enrique GuillamónDepartment of Microbiology, University of Granada, Fuente Nueva s/n, E-19071 Granada, Spain.
Alberto BañosDepartment of Microbiology, University of Granada, Fuente Nueva s/n, E-19071 Granada, Spain.ORCID 0000-0002-1691-2587
Julio GálvezDepartment of Pharmacology, Instituto de Investigación Biosanitaria (ibs. GRANADA), Center for Biomedical Research (CIBM), University of Granada, E-18071 Granada, Spain.ORCID 0000-0001-6876-3782
Pilar ViñasDepartment of Analytical Chemistry, Faculty of Chemistry, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, E-30100 Murcia, Spain.ORCID 0000-0001-5219-3711
Natalia Arroyo-ManzanaresDepartment of Analytical Chemistry, Faculty of Chemistry, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, E-30100 Murcia, Spain.
Universidad de Granada · ESUniversidad de Murcia · ESUniversidad de Jaén · ES

Funding

Spanish MICINN PGC2018-098363-B-100University of Murcia R-1328/2018
6 · The paper itself

Abstract

The present work is focused on the development of an analytical platform to elucidate the metabolic pathway of PTSO from onion, an organosulfur compound well-known for its functional and technological properties and its potential application in animal and human nutrition. This analytical platform consisted of the use of gas chromatography-mass spectrometry (GC-MS) and ultra-high performance liquid chromatography quadrupole with time-of-flight MS (UHPLC-Q-TOF-MS) in order to monitor volatile and non-volatile compounds derived from the PTSO. For the extraction of the compounds of interest, two different sample treatments were developed: liquid-liquid extraction (LLE) and salting-out assisted liquid-liquid extraction (SALLE) for GC-MS and UHPLC-Q-TOF-MS analysis, respectively. Once the analytical platform was optimised and validated, an in vivo study was planned to elucidate PTSO metabolisation, revealing the presence of dipropyl disulfide (DPDS) in liver samples with concentrations between 0.11 and 0.61 µg g

Indexed as

analytical platformin vivo studymetabolisationpropyl propane thiosulfonaterats

Identifiers

PMID36832898
PMCPMC9957255
OpenAlexW4320917830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.