ReviewDiagnostics (Basel, Switzerland)2023
The Bidirectional Relationship between Periodontal Disease and Diabetes Mellitus-A Review.
Review in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 8 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- The Effect of Diabetes on Outcomes of Non-Surgical Periodontal Therapy: A Systematic Review With a Meta-Analysis and Trial Sequential Analysis.International journal of dental hygiene · 2026Pooled it
- Association between prediabetes and periodontitis: a meta-analysis of observational studies with multivariate analysis.Medicina oral, patologia oral y cirugia bucal · 2025Pooled it
- Diabetic Retinopathy and Periodontitis: Implications from a Systematic Review and Meta-Analysis.International dental journal · 2025Pooled it
- Lipidomics in Periodontal Disease Research: A Systematic Review.Current medicinal chemistry · 2025Pooled it
- Evaluating Dickkopf-1 as a biomarker: insights into periodontitis, rheumatoid arthritis, and their comorbidity-a systematic review and meta-analysis.Frontiers in dental medicine · 2025Pooled it
- Impact of Oral Hygiene Practices in Reducing Cardiometabolic Risk, Incidence, and Mortality: A Systematic Review.International journal of environmental research and public health · 2024Pooled it
- The impact of systemic administration of polyphenols on periodontitis associated with diabetes mellitus: a systematic review.Acta odontologica Scandinavica · 2024Pooled it
- Using genetics to explore complement C5 as a druggable protein in periodontitis.Frontiers in immunology · 2024Pooled it
- Changes of Periodontal Conditions of First and Second Molars With Furcation Involvement Grade II or III - a Retrospective Analysis of 14 to 17 Year Follow-up.International journal of dental hygiene · 2026Article
- Article
- Body roundness index as a novel marker of periodontitis in US adults: NHANES 2009-2014 analysis.Medicine · 2026Article
- Clinical Implications and Research Progress of Salivary Biomarkers for Endocrine and Metabolic Disorders.Diabetes, obesity & metabolism · 2026Review
- Metabolic Syndrome and Periodontitis-From Shared Mechanisms to Interdisciplinary Care: A Narrative Review of Clinical Evidence.Journal of clinical medicine · 2026Review
- The relationship of apical periodontitis with chronic diseases and smoking habits: an umbrella review.Odontology · 2026Review
- Radiographic assessment of the relationship between alveolar bone loss and overhanging margins of posterior dental restorations in diabetic patients: a retrospective study.Oral radiology · 2026Article
- Periodontal Disease Prevalence Among Diabetic Patients: A Cross-Sectional Study at a Regional Hospital in Uganda.Cureus · 2026Article
- Article
- Exosomal microRNAs in Periodontitis: From Molecular Footprints to Clinical Frontiers.ACS pharmacology & translational science · 2026Review
- The link between dental care use and incident diabetes, cancer, and Alzheimer disease among older Americans: the health and retirement study.The Saudi dental journal · 2026Article
- Core-shell microneedles Co-loaded with simvastatin and doxycycline for combined anti-infection and osteogenesis in diabetic periodontitis.Materials today. Bio · 2026Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is a chronic inflammatory disease caused by the presence of a bacterial biofilm known as dental plaque. This biofilm affects the supporting apparatus of the teeth, especially the periodontal ligaments and the bone surrounding the teeth. Periodontal disease and diabetes seem to be interrelated and in a bidirectional relationship, and have been increasingly studied in recent decades. For example, diabetes mellitus has a detrimental effect on periodontal disease, increasing its prevalence, extent, and severity. In turn, periodontitis negatively affects glycemic control and the course of diabetes. This review aims to present the most recently discovered factors that contribute to the pathogenesis, therapy, and prophylaxis of these two diseases. Specifically, the article focuses on microvascular complications, oral microbiota, pro- and anti-inflammatory factors in diabetes, and periodontal disease. As presented in this review, these two diseases require specific/ complementary therapeutic solutions when they occur in association, with new clinical trials and epidemiological research being necessary for better control of this interdependent pathogenic topic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.