ArticleBiosensors2023
Difunctional Hydrogel Optical Fiber Fluorescence Sensor for Continuous and Simultaneous Monitoring of Glucose and pH.
Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Polymer-Based Hydrogels for Chemical Biosensing: From Bioreceptor Integration to Smart Applications.ACS applied polymer materials · 2026Review
- Non-Invasive Technologies in Wearable Glucose Monitoring: A Structured Overview for the Future.Biosensors · 2026Review
- Review
- Hydrogels-Advanced Polymer Platforms for Drug Delivery.Polymers · 2026Review
- Emerging frontiers in SERS-integrated optical waveguides: advancing portable and ultra-sensitive detection for trace liquid analysis.Light, science & applications · 2025Review
- Article
- Photopolymerization 3D-Printed Dual-Modal Flexible Sensor for Glucose and pH Monitoring.Sensors (Basel, Switzerland) · 2025Article
- Hydrogel-Based Treatment of Diabetic Wounds: From Smart Responsive to Smart Monitoring.Gels (Basel, Switzerland) · 2025Review
- Review
- Hydrogel-Based Continuum Soft Robots.Gels (Basel, Switzerland) · 2025Review
- Citrate polymer optical fiber for measuring refractive index based on LSPR sensor.Scientific reports · 2024Article
- Hydrogel for light delivery in biomedical applications.Bioactive materials · 2024Review
- The Fluorescent Detection of Glucose and Lactic Acid Based on Fluorescent Iron Nanoclusters.Sensors (Basel, Switzerland) · 2024Article
- Nanocomposite Hydrogel-Based Optical Fiber Probe for Continuous Glucose Sensing.Small science · 2024Article
- Non-Invasive Glucose Sensing Technologies and Products: A Comprehensive Review for Researchers and Clinicians.Sensors (Basel, Switzerland) · 2023Review
- Article
- Fluorescent-Nanoparticle-Impregnated Nanocomposite Polymeric Gels for Biosensing and Drug Delivery Applications.Gels (Basel, Switzerland) · 2023Review
- Biosensors Based on Inorganic Composite Fluorescent Hydrogels.Nanomaterials (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
It is significant for people with diabetes to know their body's real-time glucose level, which can guide the diagnosis and treatment. Therefore, it is necessary to research continuous glucose monitoring (CGM) as it gives us real-time information about our health condition and its dynamic changes. Here, we report a novel hydrogel optical fiber fluorescence sensor segmentally functionalized with fluorescein derivative and CdTe QDs/3-APBA, which can continuously monitor pH and glucose simultaneously. In the glucose detection section, the complexation of PBA and glucose will expand the local hydrogel and decrease the fluorescence of the quantum dots. The fluorescence can be transmitted to the detector by the hydrogel optical fiber in real time. As the complexation reaction and the swelling-deswelling of the hydrogel are all reversible, the dynamic change of glucose concentration can be monitored. For pH detection, the fluorescein attached to another segment of the hydrogel exhibits different protolytic forms when pH changes and the fluorescence changes correspondingly. The significance of pH detection is compensation for pH errors in glucose detection because the reaction between PBA and glucose is sensitive to pH. The emission peaks of the two detection units are 517 nm and 594 nm, respectively, so there is no signal interference between them. The sensor can continuously monitor glucose in 0-20 mM and pH in 5.4-7.8. The advantages of this sensor are multi-parameter simultaneous detection, transmission-detection integration, real-time dynamic detection, and good biocompatibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.