Evidence map›Paper›PMID 36832050›Full record

ReviewBiosensors2023

Cortisol Immunosensors: A Literature Review.

Chrysoula-Evangelia Karachaliou, Georgios Koukouvinos, Dimitrios Goustouridis, Ioannis Raptis, Sotirios Kakabakos, Panagiota Petrou, Evangelia Livaniou

Open access · goldAbstract readReview
In one paragraph

Review in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Cortisol Stability at 16 and 30 Years in Urine Specimens Stored at -20°C.American journal of human biology : the official journal of the Human Biology Council · 2026
    Article
  5. Article
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chrysoula-Evangelia KarachaliouImmunopeptide Chemistry Lab., Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research ''Demokritos", P.O. Box 60037, 153 10 Agia Paraskevi, Greece.ORCID 0000-0002-0939-9009
Georgios KoukouvinosImmunoassay/Immunosensors Lab., Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research ''Demokritos", P.O. Box 60037, 153 10 Agia Paraskevi, Greece.ORCID 0000-0002-2418-1876
Dimitrios GoustouridisThetaMetrisis S.A., Christou Lada 40, 121 32 Athens, Greece.
Ioannis RaptisThetaMetrisis S.A., Christou Lada 40, 121 32 Athens, Greece.
Sotirios KakabakosImmunoassay/Immunosensors Lab., Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research ''Demokritos", P.O. Box 60037, 153 10 Agia Paraskevi, Greece.ORCID 0000-0002-0043-3119
Panagiota PetrouImmunoassay/Immunosensors Lab., Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research ''Demokritos", P.O. Box 60037, 153 10 Agia Paraskevi, Greece.
Evangelia LivaniouImmunopeptide Chemistry Lab., Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research ''Demokritos", P.O. Box 60037, 153 10 Agia Paraskevi, Greece.ORCID 0000-0003-0165-9029
National Centre of Scientific Research "Demokritos" · GRUniversity of West Attica · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cortisol is a steroid hormone that is involved in a broad range of physiological processes in human/animal organisms. Cortisol levels in biological samples are a valuable biomarker, e.g., of stress and stress-related diseases; thus, cortisol determination in biological fluids, such as serum, saliva and urine, is of great clinical value. Although cortisol analysis can be performed with chromatography-based analytical techniques, such as liquid chromatography-tandem mass spectrometry (LC-MS/MS), conventional immunoassays (radioimmunoassays (RIAs), enzyme-linked immunosorbent assays (ELISAs), etc.) are considered the "gold standard" analytical methodology for cortisol, due to their high sensitivity along with a series of practical advantages, such as low-cost instrumentation, an assay protocol that is fast and easy to perform, and high sample throughput. Especially in recent decades, research efforts have focused on the replacement of conventional immunoassays by cortisol immunosensors, which may offer further improvements in the field, such as real-time analysis at the point of care (e.g., continuous cortisol monitoring in sweat through wearable electrochemical sensors). In this review, most of the reported cortisol immunosensors, mainly electrochemical and also optical ones, are presented, focusing on their immunosensing/detection principles. Future prospects are also briefly discussed.

Indexed as

Biosensing TechniquesHydrocortisoneChromatography, LiquidHumansImmunoassayTandem Mass SpectrometryHydrocortisonebiological samplesbiomarkersblood plasma/serumcortisolelectrochemical immunosensorsimmunoassaysoptical immunosensorssalivasweat

Identifiers

PMID36832050
PMCPMC9954523
OpenAlexW4321249052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.