Evidence map›Paper›PMID 36832000›Full record

ArticleBiosensors2023

Ultrafast Nucleic Acid Detection Equipment with Silicon-Based Microfluidic Chip.

Jiali Zhang, Zhuo Yang, Liying Liu, Tinglu Zhang, Lilei Hu, Chunrui Hu, Hu Chen, Ruihua Ding, Bo Liu, Chang Chen

Abstract read
In one paragraph

Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiali ZhangSchool of Microelectronics, Shanghai University, Shanghai 201800, China.ORCID 0000-0001-8877-426X
Zhuo YangSchool of Microelectronics, Shanghai University, Shanghai 201800, China.ORCID 0000-0002-6213-2733
Liying LiuShanghai Si-Gene Biotechnology Co., Ltd., Shanghai 201800, China.
Tinglu ZhangShanghai Industrial Technology Research Institute (SITRI), Shanghai 201800, China.
Lilei HuSchool of Microelectronics, Shanghai University, Shanghai 201800, China.
Chunrui HuSchool of Microelectronics, Shanghai University, Shanghai 201800, China.
Hu ChenShanghai Si-Gene Biotechnology Co., Ltd., Shanghai 201800, China.
Ruihua DingShanghai Industrial Technology Research Institute (SITRI), Shanghai 201800, China.
Bo LiuSchool of Microelectronics, Shanghai University, Shanghai 201800, China.
Chang ChenSchool of Microelectronics, Shanghai University, Shanghai 201800, China.ORCID 0000-0002-9988-930X

Funding

National Key Research and Development Program of China 2021YFB3202504National Key Research and Development Program of China 2022YFE0107400the National Key Research and Development project GJJSTD20210006the Shanghai Science and Technology Committee 20DZ2220500the Shanghai Science and Technology Committee 21NL2600100
6 · The paper itself

Abstract

Recently, infectious diseases, such as COVID-19, monkeypox, and Ebola, are plaguing human beings. Rapid and accurate diagnosis methods are required to preclude the spread of diseases. In this paper, an ultrafast polymerase chain reaction (PCR) equipment is designed to detect virus. The equipment consists of a silicon-based PCR chip, a thermocycling module, an optical detection module, and a control module. Silicon-based chip, with its thermal and fluid design, is used to improve detection efficiency. A thermoelectric cooler (TEC), together with a computer-controlled proportional-integral-derivative (PID) controller, is applied to accelerate the thermal cycle. A maximum of four samples can be tested simultaneously on the chip. Two kinds of fluorescent molecules can be detected by optical detection module. The equipment can detect viruses with 40 PCR amplification cycles in 5 min. The equipment is portable, easily operated, and low equipment cost, which shows great potential in epidemic prevention.

Indexed as

COVID-19Microfluidic Analytical TechniquesNucleic AcidsVirusesEquipment DesignHumansMicrofluidicsNucleic Acid Amplification TechniquesPolymerase Chain ReactionSiliconNucleic AcidsSiliconmicrofluidic Chipnucleic acid amplification detectionpolymerase chain reaction (PCR)ultrafast PCR equipment

Identifiers

PMID36832000
PMCPMC9954191

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.