Evidence map›Paper›PMID 36831929›Full record

ArticleBiosensors2023

A Schematic Colorimetric Assay for Sialic Acid Assay Based on PEG-Mediated Interparticle Crosslinking Aggregation of Gold Nanoparticles.

Shixing Tang, Lin Li, Rui Wang, Sagar Regmi, Xinyu Zhang, Guoqiang Yang, Jian Ju

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Shixing TangSchool of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou 325035, China.
Lin LiSchool of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou 325035, China.
Rui WangSchool of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou 325035, China.
Sagar RegmiDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0001-5104-6613
Xinyu ZhangEngineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.
Guoqiang YangSchool of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou 325035, China.
Jian JuEngineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.
Wenzhou Medical University · CNUniversity of Chinese Academy of Sciences · CNCase Western Reserve University · US

Funding

start-up grant of Wenzhou Institute, University of Chinese Academy of Sciences WIUCASQD2020018start-up grant of Wenzhou Institute, University of Chinese Academy of Sciences WIUCASQD2021027Wenzhou Public Welfare Basic Research Program S20220021
6 · The paper itself

Abstract

Sialic acid (SA) is a well-known component of glycoproteins, which have applications in various functional processes on the cell's surface. The colorimetric is a simpler and more convenient method for measuring SA due to its low-cost apparatus and visual signal changes. This work focused on the unpredictable interparticle crosslinking aggregation of the functionalized gold nanoparticles (AuNPs) in complex media. We proposed a balance of the Derjaguin-Landau-Verwey-Overbeek (DLVO)-type aggregation and molecule-based interaction method to solve this problem. Here, we report a novel colorimetric assay for the determination of SA using 4-mercaptophenyl boronic acid (4-MPBA) as an analyte's recognition molecule, and negative charge PEG

Indexed as

GoldMetal NanoparticlesBoronic AcidsColorimetryN-Acetylneuraminic AcidBoronic AcidsGoldN-Acetylneuraminic Acid4-Mercaptophenyl boronic acidcolorimetric assaygold nanoparticlespolyethylene glycol 400repulsive the interparticle crosslinkingsialic acid

Identifiers

PMID36831929
PMCPMC9953623
OpenAlexW4317617510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.