Evidence map›Paper›PMID 36831917›Full record

ArticleBiosensors2023

Selective In Vitro and Ex Vivo Staining of Brain Neurofibrillary Tangles and Amyloid Plaques by Novel Ethylene Ethynylene-Based Optical Sensors.

Florencia A Monge, Adeline M Fanni, Patrick L Donabedian, Jonathan Hulse, Nicole M Maphis, Shanya Jiang, Tia N Donaldson, Benjamin J Clark, David G Whitten, Kiran Bhaskar and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Florencia A MongeBiomedical Engineering Graduate Program, University of New Mexico, Albuquerque, NM 87131, USA.
Adeline M FanniBiomedical Engineering Graduate Program, University of New Mexico, Albuquerque, NM 87131, USA.
Patrick L DonabedianCenter for Biomedical Engineering, University of New Mexico, Albuquerque, NM 87131, USA.
Jonathan HulseMolecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, USA.ORCID 0000-0001-6184-2058
Nicole M MaphisMolecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, USA.
Shanya JiangDepartment of Neuroscience, University of New Mexico, Albuquerque, NM 87131, USA.
Tia N DonaldsonDepartment of Psychology, University of New Mexico, Albuquerque, NM 87131, USA.
Benjamin J ClarkDepartment of Psychology, University of New Mexico, Albuquerque, NM 87131, USA.ORCID 0000-0002-2662-8520
David G WhittenCenter for Biomedical Engineering, University of New Mexico, Albuquerque, NM 87131, USA.
Kiran BhaskarDepartment of Neuroscience, University of New Mexico, Albuquerque, NM 87131, USA.
Eva Y ChiCenter for Biomedical Engineering, University of New Mexico, Albuquerque, NM 87131, USA.
University of New Mexico · US

Funding

Neuropathology CoreP30AG013854 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BIGIO, EILEEN H. · 1996 to 2020
$28.9M
Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI June Bryan de la Pena · 2017 to 2026
$24.9M
FAIR Data Competency and Machine Learning Readiness for Biomedical ScientistsK12GM088021 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI REBECCA S. HARTLEY, Diane Lidke · 2009 to 2026
$16.4M
Biology of Infectious Diseases &InflammationT32AI007538 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Michelle A Ozbun · 1998 to 2026
$5.2M
Scientific CoreP20AG068077 · NIA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2020 to 2022
$3.1M
The Role of Inflammasome Signaling in TauopathiesRF1NS083704 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BHASKAR, KIRAN · 2020 to 2020
$2.7M
The role of inflammasome signaling in tauopathiesR01NS083704 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BHASKAR, KIRAN · 2014 to 2018
$1.4M
Novel Sensors for Detecting Protein Aggregates in Neurodegenerative DiseasesR21NS111267 · NINDS · UNIVERSITY OF NEW MEXICO · PI CHI, EVA YUNGHUA · 2019 to 2019
$402k
NIAID NIH HHS T32 AI007538NIA NIH HHS P20 AG068077NIA NIH HHS P20AG068077-01NIA NIH HHS P30 AG013854NIA NIH HHS P30AG013854NIGMS NIH HHS K12 GM088021NIGMS NIH HHS P20 GM121176NINDS NIH HHS R01 NS083704NINDS NIH HHS R01NS083704NINDS NIH HHS R21 NS111267NINDS NIH HHS R21NS111267NINDS NIH HHS RF1 NS083704NINDS NIH HHS RF1NS083704
6 · The paper itself

Abstract

The identification of protein aggregates as biomarkers for neurodegeneration is an area of interest for disease diagnosis and treatment development. In this work, we present novel super luminescent conjugated polyelectrolyte molecules as ex vivo sensors for tau-paired helical filaments (PHFs) and amyloid-β (Aβ) plaques. We evaluated the use of two oligo-p-phenylene ethynylenes (OPEs), anionic OPE

Indexed as

Alzheimer DiseaseNeurofibrillary TanglesAmyloid beta-PeptidesAnimalsBrainEthylenesHumansMicePlaque, AmyloidRatsStaining and Labelingtau ProteinsAmyloid beta-PeptidesEthylenestau Proteinsamyloid plaquesbiosensorsdyesfluorescence imagingneurofibrillary tanglesoptical imagingpaired helical filamentstau

Identifiers

PMID36831917
PMCPMC9953543
OpenAlexW4317425602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.