Evidence map›Paper›PMID 36831912›Full record

ArticleBrain sciences2023

A Case of Anti-GAD 65 Autoimmune Encephalitis Associated with Focal Segmental Stiff-Person Syndrome.

Chen Zhang, Yuwei Dai, Binhong Han, Jian Peng, Jie Ma, Qi Tang, Li Yang

Open access · goldAbstract readCase Reports
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  7. Decoding Dystonia in Autoimmune Disorders: A Scoping Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chen ZhangDepartment of Neurology, The Second Xiangya Hospital of Central South University, Central South University, No. 139 Middle Renmin Road, Changsha 410011, China.
Yuwei DaiDepartment of Neurology, The Second Xiangya Hospital of Central South University, Central South University, No. 139 Middle Renmin Road, Changsha 410011, China.
Binhong HanDepartment of Neurology, The Second Xiangya Hospital of Central South University, Central South University, No. 139 Middle Renmin Road, Changsha 410011, China.
Jian PengDepartment of Neurology, The Second Xiangya Hospital of Central South University, Central South University, No. 139 Middle Renmin Road, Changsha 410011, China.
Jie MaDepartment of Neurology, The Second Xiangya Hospital of Central South University, Central South University, No. 139 Middle Renmin Road, Changsha 410011, China.
Qi TangDepartment of Neurology, The Second Xiangya Hospital of Central South University, Central South University, No. 139 Middle Renmin Road, Changsha 410011, China.
Li YangDepartment of Neurology, The Second Xiangya Hospital of Central South University, Central South University, No. 139 Middle Renmin Road, Changsha 410011, China.ORCID 0000-0001-5973-3653
Central South University · CN

Funding

National Natural Science Foundation of China 81971696Natural Science Foundation of Hunan Province 2022JJ30861
6 · The paper itself

Abstract

Glutamic acid decarboxylase (GAD) antibody-related encephalitis is an autoimmune disease associated with intracellular neuronal antigens. We report on a rare case of GAD antibody-associated encephalitis complicated with focal segmental stiffness-person syndrome (SPS) in a middle-aged woman. The disease course lasted for >10 years, initially presenting with drug-resistant epilepsy, followed by stiffness of the right lower limb, and right upper limb involvement. The patient experienced anxiety and depression symptoms due to long-term illness. During hospitalization, serum and cerebrospinal fluid GAD antibodies were positive and no tumor was found. The symptoms were significantly relieved after corticosteroid therapy and intravenous immunoglobulin immunomodulation therapy. To the best of our knowledge, this case is the first to discuss the early recognition and treatment of chronic epilepsy and focal segmental SPS caused by anti-GAD antibody-related encephalitis.

Indexed as

encephalitisepilepsyglutamic acid decarboxylaserecognition and treatmentstiffness-person syndrome

Identifiers

PMID36831912
PMCPMC9954581
OpenAlexW4321459997

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.