Evidence map›Paper›PMID 36831892›Full record

ReviewBrain sciences2023

Combining Transcranial Magnetic Stimulation and Deep Brain Stimulation: Current Knowledge, Relevance and Future Perspectives.

Valentina D'Onofrio, Nicoletta Manzo, Andrea Guerra, Andrea Landi, Valentina Baro, Sara Määttä, Luca Weis, Camillo Porcaro, Maurizio Corbetta, Angelo Antonini and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Valentina D'OnofrioPadova Neuroscience Center (PNC), University of Padova, 35129 Padova, Italy.ORCID 0000-0002-5898-0967
Nicoletta ManzoIRCCS San Camillo Hospital, Via Alberoni 70, 0126 Venice, Italy.
Andrea GuerraIRCCS Neuromed, 86077 Pozzilli, Italy.ORCID 0000-0001-6601-4964
Andrea LandiAcademic Neurosurgery, Department of Neurosciences, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-7185-7779
Valentina BaroAcademic Neurosurgery, Department of Neurosciences, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-5642-4289
Sara MäättäDepartment of Clinical Neurophysiology, Kuopio University Hospital, University of Eastern Finland, 70211 Kuopio, Finland.
Luca WeisParkinson's Disease and Movement Disorders Unit, Department of Neuroscience, Centre for Rare Neurological Diseases (ERN-RND), University of Padova, 35128 Padova, Italy.
Camillo PorcaroPadova Neuroscience Center (PNC), University of Padova, 35129 Padova, Italy.
Maurizio CorbettaPadova Neuroscience Center (PNC), University of Padova, 35129 Padova, Italy.
Angelo AntoniniParkinson's Disease and Movement Disorders Unit, Department of Neuroscience, Centre for Rare Neurological Diseases (ERN-RND), University of Padova, 35128 Padova, Italy.
Florinda FerreriDepartment of Clinical Neurophysiology, Kuopio University Hospital, University of Eastern Finland, 70211 Kuopio, Finland.ORCID 0000-0002-7938-905X
University of Padua · ITIRCCS San Camillo Hospital · ITIstituto Neurologico Mediterraneo · ITUniversity of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep brain stimulation (DBS) has emerged as an invasive neuromodulation technique for the treatment of several neurological disorders, but the mechanisms underlying its effects remain partially elusive. In this context, the application of Transcranial Magnetic Stimulation (TMS) in patients treated with DBS represents an intriguing approach to investigate the neurophysiology of cortico-basal networks. Experimental studies combining TMS and DBS that have been performed so far have mainly aimed to evaluate the effects of DBS on the cerebral cortex and thus to provide insights into DBS's mechanisms of action. The modulation of cortical excitability and plasticity by DBS is emerging as a potential contributor to its therapeutic effects. Moreover, pairing DBS and TMS stimuli could represent a method to induce cortical synaptic plasticity, the therapeutic potential of which is still unexplored. Furthermore, the advent of new DBS technologies and novel treatment targets will present new research opportunities and prospects to investigate brain networks. However, the application of the combined TMS-DBS approach is currently limited by safety concerns. In this review, we sought to present an overview of studies performed by combining TMS and DBS in neurological disorders, as well as available evidence and recommendations on the safety of their combination. Additionally, we outline perspectives for future research by highlighting knowledge gaps and possible novel applications of this approach.

Indexed as

deep brain stimulation (DBS)neuromodulationneuropsychiatric disorderstranscranial magnetic stimulation (TMS)

Identifiers

PMID36831892
PMCPMC9954740
OpenAlexW4321373446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.