Evidence map›Paper›PMID 36831872›Full record

ArticleBrain sciences2023

Embryoid Body Cells from Human Embryonic Stem Cells Overexpressing Dopaminergic Transcription Factors Survive and Initiate Neurogenesis via Neural Rosettes in the Substantia Nigra.

Rodrigo Ramos-Acevedo, Carmen Alejandra Morato-Torres, Francisco J Padilla-Godínez, Luis Daniel Bernal-Conde, Marcela Palomero-Rivero, Faria Zafar, Omar Collazo-Navarrete, Luis O Soto-Rojas, Birgitt Schüle, Magdalena Guerra-Crespo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Rodrigo Ramos-AcevedoDepartment of Physiology, Faculty of Medicine, National Autonomous University of Mexico, Coyoacan, Mexico City 04510, Mexico.
Carmen Alejandra Morato-TorresDepartment of Physiology, Faculty of Medicine, National Autonomous University of Mexico, Coyoacan, Mexico City 04510, Mexico.
Francisco J Padilla-GodínezDepartment of Physiology, Faculty of Medicine, National Autonomous University of Mexico, Coyoacan, Mexico City 04510, Mexico.ORCID 0000-0002-9253-2463
Luis Daniel Bernal-CondeDepartment of Physiology, Faculty of Medicine, National Autonomous University of Mexico, Coyoacan, Mexico City 04510, Mexico.
Marcela Palomero-RiveroDepartment of Molecular Neuropathology, Institute of Cell Physiology, National Autonomous University of Mexico, Coyoacan, Mexico City 04510, Mexico.
Faria ZafarDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Omar Collazo-NavarreteNational Laboratory of Genomic Resources, Institute of Biomedical Research, National Autonomous University of Mexico, Coyoacan, Mexico City 04510, Mexico.
Luis O Soto-RojasLaboratory of Molecular Pathogenesis, Laboratory 4, Building A4, Medical Surgeon Career, Faculty of Higher Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla 54090, State of Mexico, Mexico.ORCID 0000-0002-5013-3608
Birgitt SchüleDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-9952-5776
Magdalena Guerra-CrespoDepartment of Physiology, Faculty of Medicine, National Autonomous University of Mexico, Coyoacan, Mexico City 04510, Mexico.
Universidad Nacional Autónoma de México · MXStanford University · US

Funding

Consejo Nacional de Ciencia y Tecnología A1-S-10064Consejo Nacional de Ciencia y Tecnología CVU 1037918Consejo Nacional de Ciencia y Tecnología CVU 699541Consejo Nacional de Ciencia y Tecnología CVU 767791Consejo Nacional de Ciencia y Tecnología CVU 768446DGAPA-PAPIIT IA205423DGAPA-PAPIIT IN211419DGAPA-PAPIIT IN219623
6 · The paper itself

Abstract

Transplantation of immature dopaminergic neurons or neural precursors derived from embryonic stem cells (ESCs) into the substantia nigra pars compacta (SNpc) is a potential therapeutic approach for functional restitution of the nigrostriatal pathway in Parkinson's disease (PD). However, further studies are needed to understand the effects of the local microenvironment on the transplanted cells to improve survival and specific differentiation in situ. We have previously reported that the adult SNpc sustains a neurogenic microenvironment. Non-neuralized embryoid body cells (EBCs) from mouse ESCs (mESCs) overexpressing the dopaminergic transcription factor

Indexed as

embryoid body cellshuman embryonic stem cellsneural rosettesstem-cell transplantationsubstantia nigratranscription factors

Identifiers

PMID36831872
PMCPMC9954545
OpenAlexW4320919409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.