Evidence map›Paper›PMID 36831843›Full record

ArticleBrain sciences2023

Altered Spontaneous Brain Activity in Poststroke Aphasia: A Resting-State fMRI Study.

Haozheng Li, Hui Zhang, Shuai Xu, Mengxing Wang, Jilei Zhang, Jianren Liu, Xiaoxia Du, Ruiping Hu

Abstract read
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

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0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Syntactic Scrambling in Broca's Aphasia: A Turkish Sample.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2025
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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Haozheng LiDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.ORCID 0000-0002-0899-2564
Hui ZhangShanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai 200062, China.
Shuai XuShanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai 200062, China.
Mengxing WangShanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai 200062, China.
Jilei ZhangShanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai 200062, China.
Jianren LiuDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Xiaoxia DuDepartment of Psychology, Shanghai University of Sport, Shanghai 200438, China.
Ruiping HuDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.

Funding

National Natural Science Foundation of China 81571658National Natural Science Foundation of China 82272607National Social Science Fund of China 15ZDB016Shanghai Municipal Health and Family Planning Commission 2015ZB0401the East China Normal University 2014 Key Laboratory of the Ministry of Education Open Project 2014the key projects of Shanghai Science and Technology on Biomedicine 16411955400
6 · The paper itself

Abstract

purposeBrain areas frequently implicated in language recovery after stroke comprise perilesional sites in the left hemisphere and homotopic regions in the right hemisphere. However, the neuronal mechanisms underlying language restoration are still largely unclear. METHODS AND MATERIALS: In the present study, we investigated the brain function in 15 patients with poststroke aphasia and 30 matched control subjects by combining the regional homogeneity (ReHo) and amplitudes of low-frequency fluctuation (ALFF) analysis methods based on resting-state fMRI.

resultsCompared to the control subjects, the patients with aphasia exhibited increased ReHo and ALFF values in the ipsilateral perilesional areas and increased ReHo in the contralesional right middle frontal gyrus.

conclusionsThe increased spontaneous brain activity in patients with poststroke aphasia during the recovery period, specifically in the ipsilateral perilesional regions and the homologous language regions of the right hemisphere, has potential implications for the treatment of patients with aphasia.

Indexed as

brain functionfunctional magnetic resonance imaginglow-frequency fluctuationpoststroke aphasiaregional homogeneity

Identifiers

PMID36831843
PMCPMC9954170

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.