Evidence map›Paper›PMID 36831829›Full record

ArticleBrain sciences2023

CDC42 Might Be a Molecular Signature of DWI-FLAIR Mismatch in a Nonhuman Primate Stroke Model.

Haiping Huang, Shuang Wu, Chengwei Liang, Chao Qin, Ziming Ye, Jingqun Tang, Xiangren Chen, Xiaoyun Xie, Cilan Wang, Jinfeng Fu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Haiping HuangDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Shuang WuDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Chengwei LiangDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Chao QinDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Ziming YeDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Jingqun TangDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Xiangren ChenDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Xiaoyun XieDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Cilan WangDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Jinfeng FuDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Mengyu DengDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Jingli LiuDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.ORCID 0000-0002-3094-3021
Guangxi Medical University · CN

Funding

The National Natural Science Foundation of China 82160236
6 · The paper itself

Abstract

No definitive blood markers of DWI-FLAIR mismatch, a pivotal indicator of salvageable ischemic penumbra brain tissue, are known. We previously reported that CDC42 and RHOA are associated with the ischemic penumbra. Here, we investigated whether plasma CDC42 and RHOA are surrogate markers of DWI-FLAIR mismatch. Sixteen cynomolgus macaques (3 as controls and 13 for the stroke model) were included. Guided by digital subtraction angiography (DSA), a middle cerebral artery occlusion (MCAO) model was established by occluding the middle cerebral artery (MCA) with a balloon. MRI and neurological deficit scoring were performed to evaluate postinfarction changes. Plasma CDC42 and RHOA levels were measured by enzyme-linked immunosorbent assay (ELISA). The stroke model was successfully established in eight monkeys. Based on postinfarction MRI images, experimental animals were divided into a FLAIR (-) group (

Indexed as

CDC42DWI-FLAIR mismatchischemic strokenonhuman primateRHOA

Identifiers

PMID36831829
PMCPMC9954026
OpenAlexW4319786518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.