ArticleBrain sciences2023
A Pooled Analysis of Preoperative Inflammatory Biomarkers to Predict 90-Day Outcomes in Patients with an Aneurysmal Subarachnoid Hemorrhage: A Single-Center Retrospective Study.
Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- Blood-based biomarkers for predicting prognosis in patients with subarachnoid hemorrhage: a systematic review and network meta-analysis.Journal of neurology · 2026Pooled it
- Association between systemic immune-inflammation index, systemic inflammation response index, and adverse outcomes in aneurysmal subarachnoid hemorrhage: a meta-analysis.Frontiers in neurology · 2025Pooled it
- Does the Integration of Inflammatory Markers with Clinical Scoring Systems Improve the Prediction of Neurosurgical Intervention in Emergency Department Patients Diagnosed with Traumatic Subarachnoid Hemorrhage?Diagnostics (Basel, Switzerland) · 2026Article
- Systemic inflammation response index as an independent predictor of unfavorable prognosis and its application in risk stratification in patients with aneurysmal subarachnoid hemorrhage.Frontiers in neuroscience · 2026Article
- Article
- Development of a Clinical and Laboratory-Based Predictive Nomogram Model for Unfavorable Functional Outcomes Among Patients Who Undergo Interventions for Aneurysmal Subarachnoid Hemorrhage.Journal of clinical medicine · 2025Article
- Development and validation of a machine-learning model for predicting postoperative pneumonia in aneurysmal subarachnoid hemorrhage.Neurosurgical review · 2024Article
- Prognostic value of platelet levels in patients with aneurysmal Subarachnoid Hemorrhage.Scientific reports · 2024Article
- Association Between Monocyte-to-Lymphocyte Ratio and Hematoma Progression After Cerebral Contusion.Neurocritical care · 2024Article
- A prognostic model incorporating the albumin-corrected anion gap in patients with aneurysmal subarachnoid hemorrhage.Frontiers in neurology · 2024Article
- Prognostic model for aneurysmal subarachnoid hemorrhage patients requiring mechanical ventilation.Annals of clinical and translational neurology · 2023Article
- Potential application of peripheral blood biomarkers in intracranial aneurysms.Frontiers in neurology · 2023Review
- Inflammatory Burden Index: Association Between Novel Systemic Inflammatory Biomarkers and Prognosis as Well as in-Hospital Complications of Patients with Aneurysmal Subarachnoid Hemorrhage.Journal of inflammation research · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
An inflammatory response after an aneurysmal subarachnoid hemorrhage (aSAH) has always been in the spotlight. However, few studies have compared the prognostic impact of inflammatory biomarkers. Moreover, why these inflammatory biomarkers contribute to a poor prognosis is also unclear. We retrospectively reviewed aSAH patients admitted to our institution between January 2015 and December 2020. The 90-day unfavorable functional outcome was defined as a modified Rankin scale (mRS) of ≥ 3. Independent inflammatory biomarker-related risk factors associated with 90-day unfavorable outcomes were derived from a forward stepwise multivariate analysis. Receiver operating characteristic curve analysis was conducted to identify the best cut-off value of inflammatory biomarkers. Then, patients were divided into two groups according to each biomarker's cut-off value. To eliminate the imbalances in baseline characteristics, propensity score matching (PSM) was carried out to assess the impact of each biomarker on in-hospital complications. A total of 543 patients were enrolled in this study and 96 (17.7%) patients had unfavorable 90-day outcomes. A multivariate analysis showed that the white blood cell (WBC) count, the systemic inflammation response index, the neutrophil count, the neutrophil-to-albumin ratio, the monocyte count, and the monocyte-to-lymphocyte ratio were independently associated with 90-day unfavorable outcomes. The WBC count showed the best predictive ability (area under the curve (AUC) = 0.710, 95% CI = 0.652-0.769,
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