Evidence map›Paper›PMID 36831775›Full record

ArticleBrain sciences2023

Dynamic Amyloid and Metabolic Signatures of Delayed Recall Performance within the Clinical Spectrum of Alzheimer's Disease.

Marina Tedeschi Dauar, Tharick Ali Pascoal, Joseph Therriault, Jared Rowley, Sara Mohaddes, Monica Shin, Eduardo R Zimmer, Simon Fristed Eskildsen, Vladimir S Fonov, Serge Gauthier and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 4 countries.

Marina Tedeschi DauarDouglas Mental Health University Institute, 6875 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada.
Tharick Ali PascoalMcGill University, Montreal, QC H3A 0G4, Canada.
Joseph TherriaultMcGill University, Montreal, QC H3A 0G4, Canada.
Jared RowleyTranslational Neuroimaging Laboratory, 6825 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada.
Sara MohaddesTranslational Neuroimaging Laboratory, 6825 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada.
Monica ShinTranslational Neuroimaging Laboratory, 6825 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada.
Eduardo R ZimmerTranslational Neuroimaging Laboratory, 6825 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada.
Simon Fristed EskildsenCenter of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Universitetsbyen 3, 8000 Aarhus, Denmark.ORCID 0000-0003-4242-9158
Vladimir S FonovMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University St., Montreal, QC H3A 2B4, Canada.
Serge GauthierMcGill University, Montreal, QC H3A 0G4, Canada.
Judes PoirierDouglas Mental Health University Institute, 6875 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada.ORCID 0000-0002-8018-4545
Pedro Rosa-NetoDouglas Mental Health University Institute, 6875 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada.
Alzheimer’s Disease Neuroimaging Initiative
Montreal Neurological Institute and Hospital · CAAarhus University · DKDouglas Mental Health University Institute · CAMcGill University · CAMinistry of Education · BRUniversidade Federal do Rio Grande do Sul · BRUniversity of Pittsburgh · US

Funding

Alzheimer's Association NIRG-12-92090Alzheimer's Association NIRP-12-259245CIHR 159815CIHR 162303CIHR MOP-11-51-31CIHR RFN 152985Consortium canadien en neurodégénérescence associée au vieillissement MOP-11-51-31 -team 1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88881.128434/2016-01
6 · The paper itself

Abstract

Associations between pathophysiological events and cognitive measures provide insights regarding brain networks affected during the clinical progression of Alzheimer's disease (AD). In this study, we assessed patients' scores in two delayed episodic memory tests, and investigated their associations with regional amyloid deposition and brain metabolism across the clinical spectrum of AD. We assessed the clinical, neuropsychological, structural, and positron emission tomography (PET) baseline measures of participants from the Alzheimer's Disease Neuroimaging Initiative. Subjects were classified as cognitively normal (CN), or with early (EMCI) or late (LMCI) mild cognitive impairment, or AD dementia. The memory outcome measures of interest were logical memory 30 min delayed recall (LM30) and Rey Auditory Verbal Learning Test 30 min delayed recall (RAVLT30). Voxel-based [

Indexed as

Alzheimer’s diseaseamyloid PETFDG-PETmemory testsmild cognitive impairment

Identifiers

PMID36831775
PMCPMC9954101
OpenAlexW4318478165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.