ArticleBrain sciences2023
Decreased ALFF and Functional Connectivity of the Thalamus in Vestibular Migraine Patients.
Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Network localization of regional intrinsic neural activity alterations in migraine and their neurochemical correlates.Frontiers in neurology · 2026Pooled it
- The altered functional status in vestibular migraine: A meta-analysis.Brain and behavior · 2024Pooled it
- Vestibular cortex-related effective connectivity signatures: characterization and differentiation of vestibular migraine patients via magnetic resonance imaging and machine learning.The journal of headache and pain · 2026Article
- Changes in Functional Brain Activity in School-Age Children 10 Years Later: A Resting State Functional Magnetic Resonance Imaging Study.Psychiatry investigation · 2026Article
- Can video head impulse testing aid differential assessment of suspected vestibular migraine attacks?Frontiers in neurology · 2026Review
- [Clinical application of dynamic visual acuity testing in patients with vestibular migraine].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Article
- Exploring Heterogeneity in Vestibular Migraine Using Individualized Differential Structural Covariance Network Analysis.CNS neuroscience & therapeutics · 2025Article
- Resting-state fMRI reveals brain functional alterations linked to balance disorders in vestibular migraine patients.Scientific reports · 2025Article
- Brain functional alterations in early stage of coal workers' pneumoconiosis with alcoholism: insights from a resting-state fMRI investigation.Frontiers in neuroscience · 2025Article
- Combined Functional and Structural Imaging of White Matter Reveals Brain Connectivity Alterations in Fibromyalgia Patients.Journal of pain research · 2025Article
- Disrupted gray matter connectome in vestibular migraine: a combined machine learning and individual-level morphological brain network analysis.The journal of headache and pain · 2024Article
- Aberrant cerebral blood flow and functional connectivity in patients with vestibular migraine: a resting-state ASL and fMRI study.The journal of headache and pain · 2024Article
- Resting State Brain Networks under Inverse Agonist versus Complete Knockout of the Cannabinoid Receptor 1.ACS chemical neuroscience · 2024Article
- Dynamics and concordance alterations of regional brain function indices in vestibular migraine: a resting-state fMRI study.The journal of headache and pain · 2024Article
- Right-to-left shunt-associated brain functional changes in migraine: evidences from a resting-state FMRI study.Frontiers in human neuroscience · 2024Article
- Altered thalamus functional connectivity in patients with acute unilateral vestibulopathy: a resting-state fMRI study.Frontiers in neuroscience · 2024Article
- Exploration of Hippocampal Functional Connectivity Alterations in Patients with High Myopia via Seed-Based Functional Connectivity Analysis.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Brain functional connectivity patterns associated with symptoms of vestibular migraine.Frontiers in neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe thalamus has been reported to be associated with pain modulation and processing. However, the functional changes that occur in the thalamus of vestibular migraine (VM) patients remain unknown.
methodsIn total, 28 VM patients and 28 healthy controls who were matched for age and sex underwent resting-state functional magnetic resonance imaging. They also responded to standardized questionnaires aimed at assessing the clinical features associated with migraine and vertigo. Differences in the amplitude of low-frequency fluctuation (ALFF) were analyzed and brain regions with altered ALFF in the two groups were used for further analysis of whole-brain functional connectivity (FC). The relationship between clusters and clinical features was investigated by correlation analyses.
resultsThe ALFF in the thalamus was significantly decreased in the VM group versus the control group. In the VM group, the ALFF in the left thalamus negatively correlated with VM episode frequency. Furthermore, the left thalamus showed significantly weaker FC than both regions of the medial prefrontal cortex, both regions of the anterior cingulum cortex, the left superior/middle temporal gyrus, and the left temporal pole in the VM group.
conclusionsThe thalamus plays an important role in VM patients and it is suggested that connectivity abnormalities of the thalamocortical region contribute to abnormal pain information processing and modulation, transmission, and multisensory integration in patients with VM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.