Evidence map›Paper›PMID 36831595›Full record

ReviewCancers2023

Modeling Human Brain Tumors and the Microenvironment Using Induced Pluripotent Stem Cells.

Zahraa I Khamis, Drishty B Sarker, Yu Xue, Nancy Al-Akkary, Viviana D James, Changchun Zeng, Yan Li, Qing-Xiang Amy Sang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Modeling pediatric brain tumors with human stem cells.Frontiers in cellular neuroscience · 2026
    Review
  3. Review
  4. The role of stem cells in precision medicine: next-generation cancer treatment.Journal of the Egyptian National Cancer Institute · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Stem cell modeling of nervous system tumors.Disease models & mechanisms · 2024
    Review
  15. Article
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Zahraa I KhamisDepartment of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA.
Drishty B SarkerDepartment of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0001-6366-3926
Yu XueDepartment of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0001-5978-7109
Nancy Al-AkkaryLaboratory of Cancer Biology and Molecular Immunology, Department of Biochemistry, Faculty of Sciences-I, Lebanese University, Beirut, Lebanon.
Viviana D JamesDepartment of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA.
Changchun ZengDepartment of Industrial and Manufacturing Engineering, FAMU-FSU College of Engineering, Florida State University, Tallahassee, FL 32310, USA.ORCID 0000-0003-0855-3497
Yan LiDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0002-5938-8519
Qing-Xiang Amy SangDepartment of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0001-8828-0569
Florida State University · USLebanese University · LB

Funding

Florida Department of Health 21L10Florida Department of Health 9LA01
6 · The paper itself

Abstract

Brain cancer is a group of diverse and rapidly growing malignancies that originate in the central nervous system (CNS) and have a poor prognosis. The complexity of brain structure and function makes brain cancer modeling extremely difficult, limiting pathological studies and therapeutic developments. Advancements in human pluripotent stem cell technology have opened a window of opportunity for brain cancer modeling, providing a wealth of customizable methods to simulate the disease in vitro. This is achieved with the advent of genome editing and genetic engineering technologies that can simulate germline and somatic mutations found in human brain tumors. This review investigates induced pluripotent stem cell (iPSC)-based approaches to model human brain cancer. The applications of iPSCs as renewable sources of individual brain cell types, brain organoids, blood-brain barrier (BBB), and brain tumor models are discussed. The brain tumor models reviewed are glioblastoma and medulloblastoma. The iPSC-derived isogenic cells and three-dimensional (3D) brain cancer organoids combined with patient-derived xenografts will enhance future compound screening and drug development for these deadly human brain cancers.

Indexed as

brain organoidsdisease modelingdrug screening and developmenthuman brain cancerinduced pluripotent stem cell technologyisogenic cellsthree-dimensional (3D) cell culture modelstumor microenvironment

Identifiers

PMID36831595
PMCPMC9954701
OpenAlexW4321097797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.