Evidence map›Paper›PMID 36831585›Full record

ArticleCancers2023

An Integrative Analysis of Nasopharyngeal Carcinoma Genomes Unraveled Unique Processes Driving a Viral-Positive Cancer.

Xiaodong Liu, Yanjin Li, Xiang Zhou, Sinan Zhu, Neslihan A Kaya, Yun Shen Chan, Liang Ma, Miao Xu, Weiwei Zhai

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Novel Therapeutic Development for Nasopharyngeal Carcinoma.Current oncology (Toronto, Ont.) · 2025
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Xiaodong LiuSchool of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.ORCID 0000-0001-5372-9709
Yanjin LiKey Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Xiang ZhouDepartment of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Sinan ZhuCentre for Quantitative Medicine, Health Services & Systems Research, Duke-NUS Medical School, Singapore 169857, Singapore.
Neslihan A KayaGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore.
Yun Shen ChanBioland Laboratory-Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510005, China.
Liang MaKey Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0002-1428-8426
Miao XuDepartment of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Weiwei ZhaiKey Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0001-7938-0226
Chinese Academy of Sciences · CNSun Yat-sen University · CNAgency for Science, Technology and Research · SGDuke-NUS Medical School · SGGuangzhou Regenerative Medicine and Health Guangdong Laboratory · CNUniversity of Science and Technology of China · CN

Funding

National Key R&D Program of China 2018YFC1406902,2018YFC0910400 and 2019YFA0709501National Natural Science Foundation of China 32293192,32293190,31970566 and 11971459Strategic Priority Research Program of the Chinese Academy of Sciences XDPB17
6 · The paper itself

Abstract

As one of few viral-positive cancers, nasopharyngeal carcinoma (NPC) is extremely rare across the world but very frequent in several regions of the world, including Southern China (known as the Cantonese cancer). Even though several genomic studies have been conducted for NPC, their sample sizes are relatively small and systematic comparison with other cancer types has not been explored. In this study, we collected four-hundred-thirty-one samples from six previous studies and provided the first integrative analysis of NPC genomes. Combining several statistical methods for detecting driver genes, we identified 25 novel drivers for NPC, including

Indexed as

copy number variationsdriver genesgenome instabilityintegrative analysismutational signaturesNPC

Identifiers

PMID36831585
PMCPMC9953764
OpenAlexW4321096812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.