ReviewCancers2023
Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411).
Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05559411 (A Prospective Non-interventional Multicenter Cohort Study to Evaluate Different Imaging-guided Methods for Localization of Non-palpable Malignant Breast Lesions), which is not on this map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Non-interventional Multicenter Cohort Study to Evaluate Different Imaging-guided Methods for Localization of Non-palpable Malignant Breast Lesions
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Three-dimensional printing-guided surgical localization in breast-conserving surgery: A systematic review of oncologic and aesthetic outcomes.Langenbeck's archives of surgery · 2026Pooled it
- Radiofrequency identification tag localization of nonpalpable breast lesions: a systematic review and meta-analysis.European radiology experimental · 2025Pooled it
- A Prospective Randomized Trial Comparing Radioguided Occult Lesion Localization (ROLL) and Magnetic Seed Localization for the Localization of Nonpalpable Breast Lesions: Analysis of Surgical Outcomes, Patient's Perception, and Costs.Annals of surgical oncology · 2026Trial
- Article
- Study Protocol for Assessment of the Feasibility of an Intraoperative Localization Technique Using Augmented Reality in Breast-Conserving Surgery for Non-Palpable Cancer Lesions: A Feasibility Study.Health science reports · 2026Article
- Ultrasound-Visible 3D Nickel-Titanium Clip for Tumor Localization After Neoadjuvant Therapy in Early Breast Cancer: A Prospective Multicenter Real-World Study.Diagnostics (Basel, Switzerland) · 2026Article
- RADar Reflector LocalisatIOn-SCOUTAnnals of surgical oncology · 2026Observational
- Breast Cancer Surgery: Past, Present and Future-A Narrative Review.Journal of clinical medicine · 2026Review
- RFID Technology for Intraoperative Localisation of Small Colorectal Tumours: Electromagnetic Analysis and Experimental Validation.Diagnostics (Basel, Switzerland) · 2026Article
- Surgeon seniority and performance in breast-conserving surgery for non-palpable lesions: evidence from a multicenter study.Breast (Edinburgh, Scotland) · 2026Article
- AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2026.Breast care (Basel, Switzerland) · 2026Review
- Radioguided Localisation Techniques for Non-Palpable Breast Lesions: An Umbrella Review.Journal of clinical medicine · 2026Review
- Patient-specific visco-hyperelastic mechanical model for breast tumor localization in surgical planning.Bioengineering & translational medicine · 2026Article
- Locoregional Considerations for Invasive Lobular Carcinoma.Current breast cancer reports · 2026Review
- Comparative effectiveness of preoperative localization techniques for non-palpable breast lesions: multicentre real-world study.BJS open · 2025Article
- A Randomized, Single-Center, Superiority Trial of Radioactive Seed Localization Versus Wire Localization for Malignant Breast Disease.Annals of surgery · 2025Article
- SCOUTCancers · 2025Article
- Article
- [Use of imaging methods in the current screening, diagnostics and treatment of breast cancer - Professional guidelines. 5th Breast Cancer Consensus Meeting (2025)].Magyar onkologia · 2025Article
- A 3D-printed screw mechanism as an alternative method to prevent wire migration in nonpalpable breast lesion localization.BMC surgery · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgical excision of a non-palpable breast lesion requires a localization step. Among available techniques, wire-guided localization (WGL) is most commonly used. Other techniques (radioactive, magnetic, radar or radiofrequency-based, and intraoperative ultrasound) have been developed in the last two decades with the aim of improving outcomes and logistics.
methodsWe performed a systematic review on localization techniques for non-palpable breast cancer.
resultsFor most techniques, oncological outcomes such as lesion identification and clear margin rate seem either comparable with or better than for WGL, but evidence is limited to small cohort studies for some of the devices. Intraoperative ultrasound is associated with significantly higher negative margin rates in meta-analyses of randomized clinical trials (RCTs). Radioactive techniques were studied in several RCTs and are non-inferior to WGL. Smaller studies show higher patient preference towards wire-free localization, but little is known about surgeons' and radiologists' attitudes towards these techniques.
conclusionsLarge studies with an additional focus on patient, surgeon, and radiologist preference are necessary. This review aims to present the rationale for the MELODY (NCT05559411) study and to enable standardization of outcome measures for future studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.