Evidence map›Paper›PMID 36831486›Full record

ArticleCancers2023

Glucose-Regulated Protein 78 Is a Potential Serum and Imaging Marker for Early Detection of Ovarian Cancer.

Elizabeth A Paris, Janice M Bahr, Jacques S Abramowicz, Sanjib Basu, Animesh Barua

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Elizabeth A ParisDepartment of Anatomy & Cell Biology, Rush University Medical Center, Chicago, IL 60612, USA.ORCID 0000-0002-7594-2954
Janice M BahrDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Jacques S AbramowiczDepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.
Sanjib BasuDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Animesh BaruaDepartment of Anatomy & Cell Biology, Rush University Medical Center, Chicago, IL 60612, USA.
Rush University Medical Center · USUniversity of Chicago · USUniversity of Illinois Urbana-Champaign · US

Funding

Early detection of ovarian cancer by serum marker and targeted ultrasound imagingR01CA210370 · NCI · RUSH UNIVERSITY MEDICAL CENTER · PI BARUA, ANIMESH · 2016 to 2019
$1.4M
NCI NIH HHS R01 CA210370NIH HHS CA210370Swim Across America n/a
6 · The paper itself

Abstract

backgroundUnderstanding malignant transformation associated with ovarian cancer (OVCA) is important to establish early detection tests. This study examined whether expression of glucose-regulated protein 78 (GRP78, marker of cellular stress) increases during OVCA development, and whether GRP78 can be detected by targeted-transvaginal ultrasound (TVUS) imaging.

methodsNormal ovaries (

resultsCompared with normal ovaries and benign tumors, intensity of GRP78 expression was higher (

conclusionsTissue and serum levels of GRP78 increase in association with OVCA. GRP78 offers a potential serum and imaging marker for early OVCA detection.

Indexed as

chronic inflammationearly detectionglucose-regulated protein 78laying henovarian canceroxidative stresstargeted-imaging agentstransvaginal ultrasound imaging

Identifiers

PMID36831486
PMCPMC9954741
OpenAlexW4319966532

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.