Evidence map›Paper›PMID 36831445›Full record

ArticleCancers2023

Association of Multi-Phasic MR-Based Radiomic and Dosimetric Features with Treatment Response in Unresectable Hepatocellular Carcinoma Patients following Novel Sequential TACE-SBRT-Immunotherapy.

Lok-Man Ho, Sai-Kit Lam, Jiang Zhang, Chi-Leung Chiang, Albert Chi-Yan Chan, Jing Cai

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lok-Man HoFaculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong.
Sai-Kit LamResearch Institute for Smart Ageing, The Hong Kong Polytechnic University, Hong Kong.
Jiang ZhangDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong.ORCID 0000-0001-5807-1686
Chi-Leung ChiangDepartment of Clinical Oncology, School of Clinical Medicine, The University of Hong Kong, Hong Kong.ORCID 0000-0002-9836-6478
Albert Chi-Yan ChanDepartment of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong.
Jing CaiResearch Institute for Smart Ageing, The Hong Kong Polytechnic University, Hong Kong.ORCID 0000-0001-6934-0108

Funding

Project of RISA fund, The Hong Kong Polytechnic University P0043001Shenzhen Basic Research Program JCYJ20210324130209023Shenzhen-Hong Kong-Macau S&T Program (Category C) SGDX20201103095002019
6 · The paper itself

Abstract

This study aims to investigate the association of pre-treatment multi-phasic MR-based radiomics and dosimetric features with treatment response to a novel sequential trans-arterial chemoembolization (TACE) plus stereotactic body radiotherapy (SBRT) plus immunotherapy regimen in unresectable Hepatocellular Carcinoma (HCC) sub-population. Twenty-six patients with unresectable HCC were retrospectively analyzed. Radiomic features were extracted from 42 lesions on arterial phase (AP) and portal-venous phase (PVP) MR images. Delta-phase (DeltaP) radiomic features were calculated as AP-to-PVP ratio. Dosimetric data of the tumor was extracted from dose-volume-histograms. A two-sided independent Mann-Whitney U test was used to assess the clinical association of each feature, and the classification performance of each significant independent feature was assessed using logistic regression. For the 3-month timepoint, four DeltaP-derived radiomics that characterize the temporal change in intratumoral randomness and uniformity were the only contributors to the treatment response association (

Indexed as

hepatocellular carcinomaimmunotherapymagnetic resonance imagingradiomicsstereotactic body radiotherapytrans-arterial chemoembolization

Identifiers

PMID36831445
PMCPMC9954441

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.