Evidence map›Paper›PMID 36831415›Full record

ReviewCancers2023

Modulation of the Tumor-Associated Immuno-Environment by Non-Invasive Physical Plasma.

Sarah Förster, Yuequn Niu, Benedikt Eggers, Marjan Nokhbehsaim, Franz-Josef Kramer, Sander Bekeschus, Alexander Mustea, Matthias B Stope

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Tissue adhesion after surgical interventions (Review).Experimental and therapeutic medicine · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sarah FörsterDepartment of Pathology, University Hospital Bonn, 35127 Bonn, Germany.
Yuequn NiuDepartment of Pathology, University Hospital Bonn, 35127 Bonn, Germany.
Benedikt EggersDepartment of Oral, Maxillofacial and Plastic Surgery, University Hospital Bonn, 53111 Bonn, Germany.ORCID 0000-0002-4274-3801
Marjan NokhbehsaimSection of Experimental Dento-Maxillo-Facial Medicine, University Hospital Bonn, 53111 Bonn, Germany.ORCID 0000-0003-0998-1717
Franz-Josef KramerDepartment of Oral, Maxillofacial and Plastic Surgery, University Hospital Bonn, 53111 Bonn, Germany.
Sander BekeschusZIK Plasmatis, Leibniz Institute for Plasma Science and Technology (INP), 17489 Greifswald, Germany.ORCID 0000-0002-8773-8862
Alexander MusteaDepartment of Gynecology and Gynecological Oncology, University Hospital Bonn, 53127 Bonn, Germany.
Matthias B StopeDepartment of Gynecology and Gynecological Oncology, University Hospital Bonn, 53127 Bonn, Germany.
University Hospital Bonn · DELeibniz Institute for Plasma Science and Technology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past 15 years, investigating the efficacy of non-invasive physical plasma (NIPP) in cancer treatment as a safe oxidative stress inducer has become an active area of research. So far, most studies focused on the NIPP-induced apoptotic death of tumor cells. However, whether NIPP plays a role in the anti-tumor immune responses need to be deciphered in detail. In this review, we summarized the current knowledge of the potential effects of NIPP on immune cells, tumor-immune interactions, and the immunosuppressive tumor microenvironment. In general, relying on their inherent anti-oxidative defense systems, immune cells show a more resistant character than cancer cells in the NIPP-induced apoptosis, which is an important reason why NIPP is considered promising in cancer management. Moreover, NIPP treatment induces immunogenic cell death of cancer cells, leading to maturation of dendritic cells and activation of cytotoxic CD8

Indexed as

cold atmospheric plasmacold atmospheric pressure plasmaimmune cellsimmunologynon-invasive physical plasmatumor-associated immune response

Identifiers

PMID36831415
PMCPMC9953794
OpenAlexW4319599965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.