Evidence map›Paper›PMID 36831362›Full record

ArticleCancers2023

Cancer Treatment Patterns and Factors Affecting Receipt of Treatment in Older Adults: Results from the ASPREE Cancer Treatment Substudy (ACTS).

Jaidyn Muhandiramge, Erica T Warner, John R Zalcberg, Andrew Haydon, Galina Polekhina, Gijsberta J van Londen, Peter Gibbs, Wendy B Bernstein, Jeanne Tie, Jeremy L Millar and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Observational
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Jaidyn MuhandiramgeSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3168, Australia.ORCID 0000-0002-6999-802X
Erica T WarnerClinical and Translational Epidemiology Unit, MGH Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-2671-0313
John R ZalcbergSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3168, Australia.ORCID 0000-0002-6624-0782
Andrew HaydonDepartment of Medical Oncology, Alfred Hospital, Melbourne, VIC 3004, Australia.
Galina PolekhinaSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3168, Australia.ORCID 0000-0001-9535-9291
Gijsberta J van LondenDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Peter GibbsThe Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Wendy B BernsteinWalter Reed National Military Medical Center, Bethesda, MD 20814, USA.
Jeanne TieThe Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.ORCID 0000-0001-9244-2057
Jeremy L MillarSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3168, Australia.
Victoria J MarSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3168, Australia.
John J McNeilSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3168, Australia.ORCID 0000-0002-1049-5129
Robyn L WoodsSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3168, Australia.ORCID 0000-0003-1249-6149
Suzanne G OrchardSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3168, Australia.ORCID 0000-0003-0211-3183
ASPREE Investigator Group
Monash University · AUThe Alfred Hospital · AUWalter and Eliza Hall Institute of Medical Research · AUAustin Health · AUHarvard University · USUniversity of Pittsburgh · USWalter Reed National Military Medical Center · US

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
Main Administrative CoreU19AG062682 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI CHAN, ANDREW T, MCNEIL, JOHN JAMES · 2019 to 2023
$42.9M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
Monash University N/ANational Health and Medical Research Council 334047, 1127060NIA NIH HHS P30 AG024824NIA NIH HHS U01 AG029824NIA NIH HHS U19 AG062682NIH HHS P30 CA047904, U01 AG029824, U19 AG062682, 3U19 AG062682-02S1Victorian Cancer Agency N/A
6 · The paper itself

Abstract

introductionCancer treatment planning in older adults is complex and requires careful balancing of survival, quality of life benefits, and risk of treatment-related morbidity and toxicity. As a result, treatment selection in this cohort tends to differ from that for younger patients. However, there are very few studies describing cancer treatment patterns in older cohorts.

methodsWe used data from the ASPirin in Reducing Events in the Elderly (ASPREE) trial and the ASPREE Cancer Treatment Substudy (ACTS) to describe cancer treatment patterns in older adults. We used a multivariate logistic regression model to identify factors affecting receipt of treatment.

resultsOf 1893 eligible Australian and United States (US) participants with incident cancer, 1569 (81%) received some form of cancer treatment. Non-metastatic breast cancers most frequently received treatment (98%), while haematological malignancy received the lowest rates of treatment (60%). Factors associated with not receiving treatment were older age (OR 0.94, 95% CI 0.91-0.96), residence in the US (OR 0.34, 95% CI 0.22-0.54), smoking (OR 0.57, 95% CI 0.40-0.81), and diabetes (OR 0.56, 95% CI 0.39-0.80). After adjustment for treatment patterns in sex-specific cancers, sex did not impact receipt of treatment.

conclusionsThis study is one of the first describing cancer treatment patterns and factors affecting receipt of treatment across common cancer types in older adults. We found that most older adults with cancer received some form of cancer treatment, typically surgery or systemic therapy, although this varied by factors such as cancer type, age, sex, and country of residence.

Indexed as

ageingcancer treatment patternschemotherapyolder adultsradiation therapy

Identifiers

PMID36831362
PMCPMC9953887
OpenAlexW4319319460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.