Evidence map›Paper›PMID 36831357›Full record

ArticleCancers2023

Antiapoptotic Gene Genotype and Allele Variations and the Risk of Lymphoma.

Osama M Al-Amer, Rashid Mir, Abdullah Hamadi, Mohammed I Alasseiri, Malik A Altayar, Waseem AlZamzami, Mamdoh Moawadh, Sael Alatawi, Hanan A Niaz, Atif Abdulwahab A Oyouni and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Osama M Al-AmerDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 47713, Saudi Arabia.
Rashid MirDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 47713, Saudi Arabia.ORCID 0000-0002-4014-2332
Abdullah HamadiDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 47713, Saudi Arabia.ORCID 0000-0002-1095-5455
Mohammed I AlasseiriDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 47713, Saudi Arabia.ORCID 0000-0003-0406-1524
Malik A AltayarDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 47713, Saudi Arabia.ORCID 0000-0002-3394-0686
Waseem AlZamzamiDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 47713, Saudi Arabia.ORCID 0000-0002-6673-6649
Mamdoh MoawadhDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 47713, Saudi Arabia.
Sael AlatawiDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 47713, Saudi Arabia.ORCID 0000-0001-5773-5567
Hanan A NiazDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 47713, Saudi Arabia.
Atif Abdulwahab A OyouniDepartment of Biology, Faculty of Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0001-8762-4999
Othman R AlzahraniDepartment of Biology, Faculty of Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0002-2726-0473
Hanan E AlatwiDepartment of Biology, Faculty of Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.
Aishah E AlbalawiDepartment of Biology, Faculty of Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0002-7695-8691
Khalaf F AlsharifDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.ORCID 0000-0002-8156-2069
Ashraf AlbrakatiDepartment of Human Anatomy, College of Medicine, Taif University, Taif 21944, Saudi Arabia.ORCID 0000-0002-4116-7865
Yousef M HawsawiResearch Center, King Faisal Specialist Hospital and Research Center, MBC-J04, P.O. Box 40047, Jeddah 21499, Saudi Arabia.ORCID 0000-0003-1901-697X
University of Tabuk · SATaif University · SAKing Faisal Specialist Hospital & Research Centre · SA

Funding

The Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia S-1442-0001
6 · The paper itself

Abstract

backgroundThe findings of earlier investigations of antiapoptotic gene genotypes and allele variants on lymphoma risk are ambiguous. This study aimed to examine the relationship between the mutation in the antiapoptotic genes and lymphoma risk among Saudi patients.

methodsThis case-control study included 205 patients, 100 of whom had lymphoma (cases) and 105 who were healthy volunteers (controls). We used tetra amplification refractory mutation polymerase chain reaction (PCR) to identify antiapoptotic genes such as B-cell lymphoma-2 (BCL2-938 C > A), MCL1-rs9803935 T > G, and

resultsThe dominant inheritance model among cases showed that mutations in all four antiapoptotic genes were more likely to be associated with the risk of lymphoma by the odds of 2.0-, 1.98-, 3.90-, and 3.29-fold, respectively, compared to controls. Apart from the

conclusionUnlike healthy individuals, lymphoma patients are more likely to have antiapoptotic gene genotypes and allele variants, apart from

Indexed as

antiapoptotic genesBCL2BIRC5lymphomaMCL1whole exome sequencing

Identifiers

PMID36831357
PMCPMC9954290
OpenAlexW4319319425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.