Evidence map›Paper›PMID 36831355›Full record

ArticleCancers2023

Methanodibenzo[

Akshaya Murugesan, Sana Kari, Anita Shrestha, Benedicta Assoah, Konda Mani Saravanan, Monica Murugesan, Ramesh Thiyagarajan, Nuno R Candeias, Meenakshisundaram Kandhavelu

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Targeting glutamine metabolism as a potential target for cancer treatment.Journal of experimental & clinical cancer research : CR · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Akshaya MurugesanMolecular Signaling Group, Faculty of Medicine and Health Technology, Tampere University and BioMediTech, 33101 Tampere, Finland.
Sana KariMolecular Signaling Group, Faculty of Medicine and Health Technology, Tampere University and BioMediTech, 33101 Tampere, Finland.
Anita ShresthaMolecular Signaling Group, Faculty of Medicine and Health Technology, Tampere University and BioMediTech, 33101 Tampere, Finland.
Benedicta AssoahFaculty of Engineering and Natural Sciences, Tampere University, 33101 Tampere, Finland.
Konda Mani SaravananDepartment of Biotechnology, Bharath Institute of Higher Education & Research, Chennai 600073, India.ORCID 0000-0002-5541-234X
Monica MurugesanDepartment of Biotechnology, Lady Doak College, Thallakulam, Madurai 625002, India.ORCID 0000-0002-3062-8742
Ramesh ThiyagarajanDepartment of Basic Medical Sciences, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Nuno R CandeiasFaculty of Engineering and Natural Sciences, Tampere University, 33101 Tampere, Finland.ORCID 0000-0003-2414-9064
Meenakshisundaram KandhaveluMolecular Signaling Group, Faculty of Medicine and Health Technology, Tampere University and BioMediTech, 33101 Tampere, Finland.
Tampere University · FIBharath University · INPrince Sattam Bin Abdulaziz University · SA

Funding

Fundação para a Ciência e Tecnologia CEECINST/00026/2018Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior UIDB/50006/2020, UIDP/50006/2020 and PTDC/QUI-QOR/1786/2021
6 · The paper itself

Abstract

Glutamine metabolism is an important hallmark of several cancers with demonstrated antitumor activity in glioblastoma cancer cells (GBM). GBM cells regulate glutamine and use it as a major energy source for their proliferation through the glutaminolysis process. Enzymes, such as glutaminase in glutaminolysis, can be targeted by small-molecule inhibitors, thus exhibiting promising anticancer properties. The resistance to glutaminolysis demands the development of new therapeutic molecules to overcome drug resistance. Herein, we have reported a novel library of constrained methanodibenzo[

Indexed as

characterizationglutaminase inhibitorsinteractionmodelingnew dioxocin derivativessignalingsynthesis

Identifiers

PMID36831355
PMCPMC9954004
OpenAlexW4319319628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.