ArticleBiomedicines2023
A Preliminary Study on Microbiota Characteristics of Bronchoalveolar Lavage Fluid in Patients with Pulmonary Nodules Based on Metagenomic Next-Generation Sequencing.
Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Robotic-Assisted Bronchoscopy and Pulmonary Nodules Due to Atypical Infections in Coccidioidomycosis Endemic Area.CHEST pulmonary · 2026Article
- Microbiome-host interactions in different pathomic subtypes of early-stage lung adenocarcinoma.BMC pulmonary medicine · 2026Article
- Dynamic microbiome-host interactions and their associations with systemic metabolism and radiological characteristics during early lung adenocarcinoma.NPJ precision oncology · 2026Article
- A comparative study of oral and gut microbiota for differentiating benign pulmonary nodules from lung cancer.Frontiers in microbiology · 2026Article
- Utility of bronchoalveolar lavage in checkpoint inhibitor pneumonitis evaluation: a narrative review.Translational lung cancer research · 2025Review
- The emerging role of microbiota in lung cancer: a new perspective on lung cancer development and treatment.Cellular oncology (Dordrecht, Netherlands) · 2025Review
- Lung microbiome dynamics in health and lung cancer.Microbial genomics · 2025Review
- [Characteristics of bronchoalveolar lavage fluid microbial distribution at different disease stages and its relationship with immune function in children with refractoryZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- The Metabolic Potential of the Human Lung Microbiome.Microorganisms · 2024Article
- The impact of different gastrointestinal reconstruction techniques on gut microbiota after gastric cancer surgery.Frontiers in microbiology · 2024Article
- Liquid Biopsy in Lung Cancer: Biomarkers for the Management of Recurrence and Metastasis.International journal of molecular sciences · 2023Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe characteristics and roles of microbes in the occurrence and development of pulmonary nodules are still unclear.
methodsWe retrospectively analyzed the microbial mNGS results of BALF from 229 patients with pulmonary nodules before surgery, and performed a comparative analysis of lung flora between lung cancer and benign nodules according to postoperative pathology. The analysis also focused on investigating the characteristics of lung microbiota in lung adenocarcinomas with varying histopathology.
resultsThere were differences in lung microbiota between lung cancer and benign lung nodules. Bacterial diversity was lower in lung cancer than in benign lung nodules. Four species (
conclusionChanges in the abundance of lung microbiota are closely related to the development of infiltrating adenocarcinoma. Our findings provide new insights into the relationship between the changes in lung microbiota and the development of lung cancer.
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