Evidence map›Paper›PMID 36831133›Full record

ArticleBiomedicines2023

Comparison among Neuroblastoma Stages Suggests the Involvement of Mitochondria in Tumor Progression.

Stefano Cagnin, Tomas Knedlik, Caterina Vianello, Ana Paula Magalhães Rebelo, Agnese De Mario, Marta Giacomello

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Stefano CagninDepartment of Biology, University of Padua, Via U. Bassi 58/B, 35121 Padua, Italy.ORCID 0000-0001-7271-4625
Tomas KnedlikDepartment of Biology, University of Padua, Via U. Bassi 58/B, 35121 Padua, Italy.ORCID 0000-0001-7162-6631
Caterina VianelloDepartment of Biology, University of Padua, Via U. Bassi 58/B, 35121 Padua, Italy.ORCID 0000-0002-0955-0207
Ana Paula Magalhães RebeloDepartment of Biology, University of Padua, Via U. Bassi 58/B, 35121 Padua, Italy.ORCID 0000-0001-8811-4181
Agnese De MarioDepartment of Biomedical Sciences, University of Padua, Via U. Bassi 58/B, 35121 Padua, Italy.
Marta GiacomelloDepartment of Biology, University of Padua, Via U. Bassi 58/B, 35121 Padua, Italy.ORCID 0000-0002-0290-6602
University of Padua · IT

Funding

European Union's Horizon 2020, Marie Skłodowska-Curie grant agreement for financial support (No. 896745) to T.K.University of Padua STARS@Unipd Consolidator grant FIRMESs to M.G
6 · The paper itself

Abstract

Neuroblastoma (NB) is the most common extracranial tumor of early childhood and accounts for 15% of all pediatric cancer mortalities. However, the precise pathways and genes underlying its progression are unknown. Therefore, we performed a differential gene expression analysis of neuroblastoma stage 1 and stage 4 + 4S to discover biological processes associated with NB progression. From this preliminary analysis, we found that NB samples (stage 4 + 4S) are characterized by altered expression of some proteins involved in mitochondria function and mitochondria-ER contact sites (MERCS). Although further analyses remain necessary, this review may provide new hints to better understand NB molecular etiopathogenesis, by suggesting that MERCS alterations could be involved in the progression of NB.

Indexed as

cancercytoskeletondifferentially expressed genesendoplasmic reticulumMAMsMERCSmicrotubulesmitochondriamitochondria-associated membranesmitochondria–endoplasmic reticulum contact sitesmitochondrial dynamicsneuroblastoma

Identifiers

PMID36831133
PMCPMC9953471
OpenAlexW4321228505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.