ReviewBiomedicines2023
Primary Mediastinal Germ Cell Tumors: A Thorough Literature Review.
Review in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- SEOM-GG clinical guidelines for the management of germ-cell testicular cancer (2023).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Guideline
- Radiological and Biochemical Diagnosis of a Primary Mediastinal Germ Cell Tumour: A Case Report.Cureus · 2026Article
- Article
- Giant Mediastinal Teratoma in a Child: A Case Report With a Brief Review of the Literature.Clinical case reports · 2026Article
- The Morphologic Spectrum of Mediastinal Yolk Sac Tumors: Diagnostic Challenges and Pitfalls.Cancers · 2026Review
- Mediastinal Germ Cell Tumors: Up Close and Personal.JMIR cancer · 2026Review
- Small biopsy diagnosis of anterior mediastinal masses: histologic, immunohistochemical, and molecular considerations.Mediastinum (Hong Kong, China) · 2026Review
- Primary Mediastinal Seminoma: A Diagnostic and Therapeutic Challenge With an Optimistic Outcome.Case reports in oncological medicine · 2026Article
- Histopathologic diagnosis of mediastinal seminoma in a low-resource setting: A case report on navigating limited access to molecular testing.International journal of surgery case reports · 2025Article
- The FSIP Family: Roles in Health and Cancer.Cancers · 2025Review
- Primary Mediastinal Germ Cell Tumor in a Woman Presenting With Superior Vena Cava Syndrome: A Case Report.Cureus · 2025Article
- Deep learning-based super-resolution US radiomics to differentiate testicular seminoma and non-seminoma: an international multicenter study.Insights into imaging · 2025Article
- Multi-Level Oncological Management of a Rare, Combined Mediastinal Tumor: A Case Report.Current oncology (Toronto, Ont.) · 2025Article
- A mediastinal tumor with massive pericardial effusion.Internal and emergency medicine · 2025Article
- When rarity meets thoracic cancers: a narrative review from ITMIG 2024.Mediastinum (Hong Kong, China) · 2025Review
- Micronodular thymic epithelial tumors with lymphoid hyperplasia and mimicking lesions.Histology and histopathology · 2025Review
- Current Trends in the Surgical Management of Yolk Sac Tumors.Current oncology (Toronto, Ont.) · 2024Review
- Metastatic epidural spinal cord compression from testicular yolk sac tumor: case report and literature review.Journal of spine surgery (Hong Kong) · 2024Article
- Article
- The combination of maximum standardized uptake value and clinical parameters for improving the accuracy in distinguishing primary mediastinal lymphomas from thymic epithelial tumors.Quantitative imaging in medicine and surgery · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary mediastinal germ cell tumors (PMGCTs) are a rare type of cancer affecting young adults. They have different molecular and clinical features compared to testicular germ cell tumors. Non-seminoma PMGCTs have the shortest 5-year overall survival and the poorest prognosis among all of the germ cell tumor presentations, while seminomas share the same survival and prognosis as their testicular counterparts. There is an unmet need for better treatment options for patients with non-seminoma PMGCTs in both first-line and salvage therapy, as the available options are associated with underwhelming outcomes. Identifying biological and genetic factors to predict treatment responses would be helpful in improving the survival of these patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.