Evidence map›Paper›PMID 36830945›Full record

ArticleBiomedicines2023

Long-Interval Intracortical Inhibition and the Cortical Silent Period in Youth.

Kelly B Ahern, Juan F Garzon, Deniz Yuruk, Maria Saliba, Can Ozger, Jennifer L Vande Voort, Paul E Croarkin

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kelly B AhernMayo Clinic Alix School of Medicine, 200 First St. SW, Rochester, MN 55905, USA.ORCID 0000-0003-4123-5685
Juan F GarzonMayo Clinic College of Medicine and Science, 200 First St. SW, Rochester, MN 55905, USA.ORCID 0000-0003-2333-0195
Deniz YurukMayo Clinic College of Medicine and Science, 200 First St. SW, Rochester, MN 55905, USA.
Maria SalibaMayo Clinic College of Medicine and Science, 200 First St. SW, Rochester, MN 55905, USA.
Can OzgerMayo Clinic College of Medicine and Science, 200 First St. SW, Rochester, MN 55905, USA.ORCID 0000-0002-5669-9418
Jennifer L Vande VoortMayo Clinic College of Medicine and Science, 200 First St. SW, Rochester, MN 55905, USA.ORCID 0000-0002-3630-4773
Paul E CroarkinMayo Clinic College of Medicine and Science, 200 First St. SW, Rochester, MN 55905, USA.ORCID 0000-0001-6843-6503
Mayo Clinic · US

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
Glutamatergic and GABAergic Biomarkers in rTMS for Adolescent DepressionR01MH113700 · NIMH · MAYO CLINIC ROCHESTER · PI CROARKIN, PAUL E · 2017 to 2021
$2.5M
A Randomized Controlled Trial of Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents with Suicidal Ideation Associated with Major Depressive DisorderR01MH124655 · NIMH · MAYO CLINIC ROCHESTER · PI CROARKIN, PAUL E · 2020 to 2023
$2.4M
NCATS NIH HHS UL1 TR002377NIMH NIH HHS R01 MH113700NIMH NIH HHS R01MH113700 and R01MH124655NIMH NIH HHS R01 MH124655
6 · The paper itself

Abstract

backgroundThe cortical silent period (CSP) and long-interval intracortical inhibition (LICI) are putative markers of γ-aminobutyric acid receptor type B (GABA

methodsWe analyzed data from three previous studies of youth who underwent CSP and LICI measurements with transcranial magnetic stimulation and electromyography. We assessed CSP and LICI association using Spearman rank correlation tests and multiple linear regression analyses adjusted for demographic and clinical covariates.

resultsThe sample included 16 healthy participants and 45 participants with depression. The general mean (SD) age was 15.5 (1.7), 14.3 (1.7) for healthy participants, and 15.9 (1.6) years for participants with depression. Measures were nonnormally distributed (Shapiro-Wilk,

conclusionsAlthough previous studies suggest that cortical silent period and long-interval intracortical inhibition measure GABA

Indexed as

adolescentcortical inhibitionGABA-B receptorpsychiatric disorderstranscranial magnetic stimulation

Identifiers

PMID36830945
PMCPMC9953741
OpenAlexW4318485194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.