Evidence map›Paper›PMID 36830737›Full record

ArticleBiomolecules2023

Associations between Dietary Intake, Blood Levels of Omega-3 and Omega-6 Fatty Acids and Reading Abilities in Children.

Francesca Borasio, Valentina De Cosmi, Veronica D'Oria, Silvia Scaglioni, Marie-Louise Eva Syren, Stefano Turolo, Carlo Agostoni, Marilena Coniglio, Massimo Molteni, Alessandro Antonietti and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04287530 (Poly-unsaturated Fatty Acids and Developmental Dyslexia), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04287530 naunknown statusnot on this map

Poly-unsaturated Fatty Acids and Developmental Dyslexia: Correlations With Cognitive Performance and Effects of Supplementation in Addition to Neuropsychological Treatment

TypeinterventionalSponsorIRCCS Eugenio MedeaRan2020 to 2025Enrolled125ConditionsDyslexia, DevelopmentalArmsPoly-unsaturated fatty acids supplementation, Neuropsychological intervention, Placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Francesca BorasioScientific Institute IRCSS E. Medea, Unit of Child Psychopathology, 23842 Bosisio Parini, Italy.ORCID 0000-0003-0809-0752
Valentina De CosmiDepartment of Clinical and Community Sciences, University of Milan, 20122 Milan, Italy.
Veronica D'OriaFondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Anestesia e Terapia Intensiva Donna-Bambino, 20122 Milan, Italy.
Silvia ScaglioniFondazione De Marchi, Department of Pediatrics, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Marie-Louise Eva SyrenDepartment of Clinical and Community Sciences, University of Milan, 20122 Milan, Italy.ORCID 0000-0003-0857-8432
Stefano TuroloFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, SC Nephrology Dialysis and Pediatric Transplantation, 20122 Milan, Italy.ORCID 0000-0002-9178-0713
Carlo AgostoniDepartment of Clinical and Community Sciences, University of Milan, 20122 Milan, Italy.ORCID 0000-0002-5006-0832
Marilena ConiglioFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, SC Child and Adolescent Neuropsychiatry, 20122 Milan, Italy.ORCID 0000-0002-3113-7638
Massimo MolteniScientific Institute IRCSS E. Medea, Unit of Child Psychopathology, 23842 Bosisio Parini, Italy.
Alessandro AntoniettiDepartment of Psychology, Catholic University of the Sacred Heart, 20123 Milan, Italy.ORCID 0000-0002-7212-8076
Maria Luisa LorussoScientific Institute IRCSS E. Medea, Unit of Child Psychopathology, 23842 Bosisio Parini, Italy.ORCID 0000-0003-4640-306X
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversity of Milan · ITIRCCS Eugenio Medea · ITUniversità Cattolica del Sacro Cuore · IT

Funding

Italian Ministero della Salute RC 2022Italian Ministero della Salute RC 2023Ministero della Salute RC 2021
6 · The paper itself

Abstract

Lower levels of omega-3 polyunsaturated fatty acids (PUFAs) have been described in individuals with reading difficulties, but the degree and the nature of such deficiencies as well as the role of nutrition are a matter of debate. The aim of the present study was to investigate the associations between PUFA blood levels, nutritional status, and reading/writing/phonological awareness performances in 42 school-age children with varying levels of reading ability. Significant correlations were found between PUFA levels (specific omega-6/omega-3 ratios), the ratio of omega-6-derived calories to the total amount of calories and reading scores. Mediation analysis showed a mediating effect of fatty acids on the association between reading speed scores and nutritional status. Moderation analysis, moreover, showed that the associations of omega-6/omega-3 ratios in the blood and Kcal omega-6/Kcal total in dietary intake were moderated by reading speed performances. Results of the mediation and moderation models confirm that the associations of dietary intake with PUFA levels in the blood vary depending on learning abilities. Reading skills appear to be sensitive to the effects of a complex set of favorable conditions related to the presence of higher omega-3 blood levels. These conditions may reflect the action of dietary as well as genetic and epigenetic mechanisms.

Indexed as

Fatty Acids, Omega-3ReadingChildEatingFatty AcidsFatty Acids, Omega-6Fatty Acids, UnsaturatedHumansFatty AcidsFatty Acids, Omega-3Fatty Acids, Omega-6Fatty Acids, Unsaturatedblood PUFAsdietary intakedyslexiaomega-3omega-6omega-6/omega-3 ratiophonological awarenessPUFAsreadingwriting

Identifiers

PMID36830737
PMCPMC9952928
OpenAlexW4321107072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.