Evidence map›Paper›PMID 36830736›Full record

ArticleBiomolecules2023

Commonly Used Therapeutics Associated with Changes in Arousal Inhibit GABA

Anling Kaplan, Abigail I Nash, Amanda A H Freeman, Lauren G Lewicki, David B Rye, Lynn Marie Trotti, Asher L Brandt, Andrew Jenkins

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Anling KaplanDepartment of Anesthesiology, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-8957-6721
Abigail I NashDepartment of Medical Affairs, Janssen Scientific Affairs LLC, Titusville, NJ 08560, USA.
Amanda A H FreemanCenter for Human Health, Emory University, Atlanta, GA 30322, USA.
Lauren G LewickiSchool of Pharmacy, University of Saint Joseph, West Hartford, CT 06117, USA.
David B RyeDepartment of Neurology, Emory University, Atlanta, GA 30322, USA.
Lynn Marie TrottiDepartment of Neurology, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0003-2329-6847
Asher L BrandtDepartment of Chemistry, University of Saint Joseph, West Hartford, CT 06117, USA.
Andrew JenkinsDepartment of Pharmaceutical Sciences, University of Saint Joseph, West Hartford, CT 06117, USA.ORCID 0000-0003-3874-0795
Emory University · USUniversity of Saint Joseph · USJanssen (United States) · US

Funding

Antibiotic-mediated improvements in vigilance: mechanisms of action of clarithromycin in hypersomnia syndromesR01NS111280 · NINDS · EMORY UNIVERSITY · PI TROTTI, LYNN MARIE · 2019 to 2023
$2.2M
NINDS NIH HHS R01 NS111280
6 · The paper itself

Abstract

GABA

Indexed as

FlumazenilReceptors, GABA-AAllosteric RegulationArousalgamma-Aminobutyric AcidHumansFlumazenilgamma-Aminobutyric AcidReceptors, GABA-AarousalGABAGABAARGABAA receptorgamma-aminobutyric acididiopathic hypersomnianegative allosteric modulatorsleep

Identifiers

PMID36830736
PMCPMC9953295
OpenAlexW4320917023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.