Evidence map›Paper›PMID 36830734›Full record

ArticleBiomolecules2023

Cytochrome P450 Surface Domains Prevent the β-Carotene Monohydroxylase CYP97H1 of

Thomas Lautier, Derek J Smith, Lay Kien Yang, Xixian Chen, Congqiang Zhang, Gilles Truan, Nic D Lindley

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Thomas LautierSingapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore 138669, Singapore.
Derek J SmithSingapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore 138669, Singapore.
Lay Kien YangSingapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore 138669, Singapore.ORCID 0000-0002-6154-9908
Xixian ChenSingapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore 138669, Singapore.ORCID 0000-0002-0335-2058
Congqiang ZhangSingapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore 138669, Singapore.ORCID 0000-0003-1070-8806
Gilles TruanToulouse Biotechnolgy Institute, Université de Toulouse, CNRS, INRAE, INSA, 31077 Toulouse, France.ORCID 0000-0002-3560-8302
Nic D LindleySingapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore 138669, Singapore.
Agency for Science, Technology and Research · SGCentre National de la Recherche Scientifique · FR

Funding

2019 AME Young Investigator Research Grant (YIRG) A2084c0064Biotrans IAF-PP (HBMS Domain) H17/01/a0/006the National Research Foundation, Prime Minister's Office, Singapore under its Campus for Research Excellence and Technological Enterprise (CREATE) EcoCTs project
6 · The paper itself

Abstract

Molecular biodiversity results from branched metabolic pathways driven by enzymatic regioselectivities. An additional complexity occurs in metabolites with an internal structural symmetry, offering identical extremities to the enzymes. For example, in the terpene family, β-carotene presents two identical terminal closed-ring structures. Theses cycles can be hydroxylated by cytochrome P450s from the CYP97 family. Two sequential hydroxylations lead first to the formation of monohydroxylated β-cryptoxanthin and subsequently to that of dihydroxylated zeaxanthin. Among the CYP97 dihydroxylases, CYP97H1 from

Indexed as

beta CaroteneEuglena gracilisCytochrome P-450 Enzyme SystemSubstrate Specificitybeta CaroteneCytochrome P-450 Enzyme Systemasymmetric catalysiscarotenoidscytochrome P450protein engineeringregioselectivityβ-cryptoxanthin

Identifiers

PMID36830734
PMCPMC9953315
OpenAlexW4320917317

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.