Evidence map›Paper›PMID 36830698›Full record

ArticleBiomolecules2023

Reversibility and Low Commitment to Forward Catalysis in the Conjugation of Lipid Alkenals by Glutathione Transferase A4-4.

Michele Scian, Lorela Paço, Taylor A Murphree, Laura M Shireman, William M Atkins

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Unveiling the Role of GlutathioneACS pharmacology & translational science · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michele ScianDepartment of Medicinal Chemistry, University of Washington, Seattle, WA 98195-7610, USA.
Lorela PaçoDepartment of Medicinal Chemistry, University of Washington, Seattle, WA 98195-7610, USA.
Taylor A MurphreeDepartment of Medicinal Chemistry, University of Washington, Seattle, WA 98195-7610, USA.
Laura M ShiremanDepartment of Medicinal Chemistry, University of Washington, Seattle, WA 98195-7610, USA.
William M AtkinsDepartment of Medicinal Chemistry, University of Washington, Seattle, WA 98195-7610, USA.
University of Washington · US

Funding

Glutathione S-Transferases and Oxidative StressR01GM062284 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 2002 to 2011
$2.0M
NIGMS NIH HHS R01 GM062284
6 · The paper itself

Abstract

High concentrations of electrophilic lipid alkenals formed during oxidative stress are implicated in cytotoxicity and disease. However, low concentrations of alkenals are required to induce antioxidative stress responses. An established clearance pathway for lipid alkenals includes conjugation to glutathione (GSH) via Michael addition, which is catalyzed mainly by glutathione transferase isoform A4 (GSTA4-4). Based on the ability of GSTs to catalyze hydrolysis or

Indexed as

AldehydesGlutathione TransferaseAntioxidantsCatalysisGlutathioneLipidsAldehydesAntioxidantsGlutathioneGlutathione Transferaseleukotriene-C4 synthaseLipidsdeuterium exchangeenzyme detoxicationenzyme mechanismhydroxynonenallipid alkenalslipid peroxidationsubstrate promiscuity

Identifiers

PMID36830698
PMCPMC9953347
OpenAlexW4319786639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.