Evidence map›Paper›PMID 36830656›Full record

ArticleBiomolecules2023

Copper Binding and Redox Activity of α-Synuclein in Membrane-Like Environment.

Chiara Bacchella, Francesca Camponeschi, Paulina Kolkowska, Arian Kola, Isabella Tessari, Maria Camilla Baratto, Marco Bisaglia, Enrico Monzani, Luigi Bubacco, Stefano Mangani and 3 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Chiara BacchellaDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0003-3256-8699
Francesca CamponeschiDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0002-4122-4508
Paulina KolkowskaDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Arian KolaDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Isabella TessariDepartment of Biology, University of Padova, 35121 Padua, Italy.ORCID 0000-0002-5823-645X
Maria Camilla BarattoDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0003-2258-779X
Marco BisagliaDepartment of Biology, University of Padova, 35121 Padua, Italy.ORCID 0000-0002-3968-8418
Enrico MonzaniDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-8791-6446
Luigi BubaccoDepartment of Biology, University of Padova, 35121 Padua, Italy.ORCID 0000-0001-7927-9208
Stefano ManganiDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0003-4824-7478
Luigi CasellaDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-7671-0506
Simone Dell'AcquaDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-1231-4045
Daniela ValensinDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0003-4187-3919
University of Siena · ITUniversity of Pavia · ITUniversity of Padua · IT

Funding

Ministry of Education, Universities and Research PRIN 2015T778JW
6 · The paper itself

Abstract

α-Synuclein (αSyn) constitutes the main protein component of Lewy bodies, which are the pathologic hallmark in Parkinson's disease. αSyn is unstructured in solution but the interaction of αSyn with lipid membrane modulates its conformation by inducing an α-helical structure of the

Indexed as

alpha-SynucleinParkinson DiseaseCopperHumansOxidation-ReductionPeptidesalpha-SynucleinCopperPeptidescopper(I)copper(II)membrane environmentredox activitysynucleinα-helix

Identifiers

PMID36830656
PMCPMC9953312
OpenAlexW4319082886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.