Evidence map›Paper›PMID 36830589›Full record

ArticleBiomolecules2023

Using ΔK280 Tau

Zheng-Kui Weng, Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Chih-Hsin Lin, Pei-Hsuan Tseng, Ying-Chieh Sun, Wenwei Lin, Guey-Jen Lee-Chen, Chiung-Mei Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zheng-Kui WengDepartment of Life Science, National Taiwan Normal University, Taipei 106, Taiwan.
Te-Hsien LinDepartment of Neurology, Chang Gung Memorial Hospital, School of Medicine, Chang-Gung University, Taoyuan 333, Taiwan.
Kuo-Hsuan ChangDepartment of Neurology, Chang Gung Memorial Hospital, School of Medicine, Chang-Gung University, Taoyuan 333, Taiwan.ORCID 0000-0003-4972-9823
Ya-Jen ChiuDepartment of Life Science, National Taiwan Normal University, Taipei 106, Taiwan.ORCID 0000-0003-3195-2509
Chih-Hsin LinDepartment of Neurology, Chang Gung Memorial Hospital, School of Medicine, Chang-Gung University, Taoyuan 333, Taiwan.
Pei-Hsuan TsengDepartment of Life Science, National Taiwan Normal University, Taipei 106, Taiwan.
Ying-Chieh SunDepartment of Chemistry, National Taiwan Normal University, Taipei 106, Taiwan.
Wenwei LinDepartment of Chemistry, National Taiwan Normal University, Taipei 106, Taiwan.
Guey-Jen Lee-ChenDepartment of Life Science, National Taiwan Normal University, Taipei 106, Taiwan.ORCID 0000-0003-4818-9917
Chiung-Mei ChenDepartment of Neurology, Chang Gung Memorial Hospital, School of Medicine, Chang-Gung University, Taoyuan 333, Taiwan.ORCID 0000-0002-0769-0353
National Taiwan Normal University · TWChang Gung University · TW

Funding

Chang Gung Medical Foundation CMRPG3L0041-2Ministry of Science and Technology Taiwan MOST 109-2320-B-003-008Ministry of Science and Technology Taiwan MOST 109-2320-B-182A-021
6 · The paper itself

Abstract

Misfolded aggregation of the hyperphosphorylated microtubule binding protein Tau in the brain is a pathological hallmark of Alzheimer's disease (AD). Tau aggregation downregulates brain-derived neurotrophic factor (BDNF)/tropomycin receptor kinase B (TRKB) signaling and leads to neurotoxicity. Therefore, enhancement of BDNF/TRKB signaling could be a strategy to alleviate Tau neurotoxicity. In this study, eight compounds were evaluated for the potential of inhibiting Tau misfolding in human neuroblastoma SH-SY5Y cells expressing the pro-aggregator Tau folding reporter (ΔK280 Tau

Indexed as

Alzheimer DiseaseNeuroblastomaBrain-Derived Neurotrophic FactorHumansProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-bcl-2Receptor, trkBtau ProteinsBrain-Derived Neurotrophic FactorProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-bcl-2Receptor, trkBtau ProteinsAlzheimer’s diseaseBDNF-TRKB signalingheterocyclic compoundTau cell modelTRKB agonist

Identifiers

PMID36830589
PMCPMC9953660
OpenAlexW4317933332

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.