Evidence map›Paper›PMID 36830327›Full record

ReviewAntibiotics (Basel, Switzerland)2023

Bacteriophage Therapy as an Application for Bacterial Infection in China.

Shuang Liang, Yanling Qi, Huabo Yu, Wuwen Sun, Sayed Haidar Abbas Raza, Nada Alkhorayef, Samia S Alkhalil, Essam Eldin Abdelhady Salama, Lei Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Isolation and characterization of two phages infectingThe Journal of general virology · 2026
    Article
  3. Review
  4. Review
  5. Phage and endolysin-based inhibition ofFrontiers in cellular and infection microbiology · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Journal of virology · 2025
    Article
  18. New BacteriophageViruses · 2025
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Shuang LiangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun 130000, China.
Yanling QiCollege of Animal Science and Technology, Jilin Agricultural University, Changchun 130000, China.
Huabo YuCollege of Animal Science and Technology, Jilin Agricultural University, Changchun 130000, China.
Wuwen SunCollege of Animal Science and Technology, Jilin Agricultural University, Changchun 130000, China.
Sayed Haidar Abbas RazaCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.ORCID 0000-0002-0961-1911
Nada AlkhorayefDepartment of Clinical Laboratory Science, College of Applied Medical Sciences, Al-Quway'iyah, Shaqra University, Riyadh 19257, Saudi Arabia.ORCID 0000-0001-9780-9305
Samia S AlkhalilDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Shaqra University, Shaqra 11961, Saudi Arabia.ORCID 0000-0001-5811-7592
Essam Eldin Abdelhady SalamaAnatomy Department College of Medicine, King Saud University, Riyadh 11495, Saudi Arabia.ORCID 0000-0002-0728-4339
Lei ZhangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun 130000, China.
Jilin Agricultural University · CNShaqra University · SAKing Saud University · SANorthwest A&F University · CN

Funding

Jilin Province Science and Technology Department No.20210508006R Q
6 · The paper itself

Abstract

Antibiotic resistance has emerged as a significant issue to be resolved around the world. Bacteriophage (phage), in contrast to antibiotics, can only kill the target bacteria with no adverse effect on the normal bacterial flora. In this review, we described the biological characteristics of phage, and summarized the phage application in China, including in mammals, ovipara, aquatilia, and human clinical treatment. The data showed that phage had a good therapeutic effect on drug-resistant bacteria in veterinary fields, as well as in the clinical treatment of humans. However, we need to take more consideration of the narrow lysis spectrum, the immune response, the issues of storage, and the pharmacokinetics of phages. Due to the particularity of bacteriophage as a bacterial virus, there is no unified standard or regulation for the use of bacteriophage in the world at present, which hinders the application of bacteriophage as a substitute for antibiotic biological products. We aimed to highlight the rapidly advancing field of phage therapy as well as the challenges that China faces in reducing its reliance on antibiotics.

Indexed as

animal modelsanti-infectionbacterial resistanceclinical applicationphage therapy

Identifiers

PMID36830327
PMCPMC9952293
OpenAlexW4321372285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.